Evidence map›Paper›PMID 36184074›Full record

ArticleSchizophrenia bulletin2023

Emergence of Language Related to Self-experience and Agency in Autobiographical Narratives of Individuals With Schizophrenia.

Chi C Chan, Raquel Norel, Carla Agurto, Paul H Lysaker, Evan J Myers, Erin A Hazlett, Cheryl M Corcoran, Kyle S Minor, Guillermo A Cecchi

Abstract read
In one paragraph

Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Humanizing "multimodal" digital phenotyping of serious mental illness.Journal of psychopathology and clinical science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chi C ChanMental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY, USA.
Raquel NorelIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.ORCID 0000-0001-7737-4172
Carla AgurtoIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Paul H LysakerRichard L. Roudebush VA Medical Center, Indianapolis, IN, USA.
Evan J MyersDepartment of Psychology, Indiana University-Purdue University, Indianapolis, IN, USA.ORCID 0000-0003-4058-0698
Erin A HazlettMental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY, USA.
Cheryl M CorcoranMental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY, USA.
Kyle S MinorDepartment of Psychology, Indiana University-Purdue University, Indianapolis, IN, USA.
Guillermo A CecchiIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.ORCID 0000-0003-1013-8348

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Thought disorder and social cognition in clinical risk states for schizophreniaR01MH107558 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CORCORAN, CHERYL MARY · 2016 to 2020
$3.3M
Indiana Clinical and Translational Sciences InstituteKL2TR001106 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$3.2M
Computational phenotyping of face expression in early psychosisR01MH132239 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHERYL MARY CORCORAN · 2023 to 2026
$2.8M
Using the RDoC Approach to Understand Thought Disorder: A Linguistic Corpus-Based ApproachR01MH115332 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CORCORAN, CHERYL MARY · 2018 to 2020
$1.6M
CSRD VA IK6 CX001738NCATS NIH HHS KL2 TR001106NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR004419NIMH NIH HHS R01 MH107558NIMH NIH HHS R01 MH115332NIMH NIH HHS R01 MH132239
6 · The paper itself

Abstract

background and hypothesisDisturbances in self-experience are a central feature of schizophrenia and its study can enhance phenomenological understanding and inform mechanisms underlying clinical symptoms. Self-experience involves the sense of self-presence, of being the subject of one's own experiences and agent of one's own actions, and of being distinct from others. Self-experience is traditionally assessed by manual rating of interviews; however, natural language processing (NLP) offers automated approach that can augment manual ratings by rapid and reliable analysis of text. STUDY

designWe elicited autobiographical narratives from 167 patients with schizophrenia or schizoaffective disorder (SZ) and 90 healthy controls (HC), amounting to 490 000 words and 26 000 sentences. We used NLP techniques to examine transcripts for language related to self-experience, machine learning to validate group differences in language, and canonical correlation analysis to examine the relationship between language and symptoms. STUDY

resultsTopics related to self-experience and agency emerged as significantly more expressed in SZ than HC (P < 10-13) and were decoupled from similarly emerging features such as emotional tone, semantic coherence, and concepts related to burden. Further validation on hold-out data showed that a classifier trained on these features achieved patient-control discrimination with AUC = 0.80 (P < 10-5). Canonical correlation analysis revealed significant relationships between self-experience and agency language features and clinical symptoms.

conclusionsNotably, the self-experience and agency topics emerged without any explicit probing by the interviewer and can be algorithmically detected even though they involve higher-order metacognitive processes. These findings illustrate the utility of NLP methods to examine phenomenological aspects of schizophrenia.

Indexed as

MetacognitionPsychotic DisordersSchizophreniaHumansNatural Language ProcessingSemanticsartificial intelligencemachine learningnatural language processingphenomenologypsychosisself-disturbance

Identifiers

PMID36184074
PMCPMC10016400

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.