ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2022
Hepatotoxicity due to herbal dietary supplements: Past, present and the future.
Review in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic and Ethnobotanical Review of Ashwagandha's ( Withania Somnifera ) Teratogenic and Abortifacient Potentials.Phytotherapy research : PTR · 2026Pooled it
- Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements usingFEBS open bio · 2026Article
- From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat.Pharmaceutical biology · 2025Review
- Drug-Induced Liver Injury Secondary to Turmeric Supplement Containing Piperine: A Case Report.Cureus · 2025Article
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract.Drug and chemical toxicology · 2025Article
- Mercury Levels in Selected Medicines and Dietary Supplements in Poland.Biological trace element research · 2025Article
- Hepatotoxicity of usnic acid and underlying mechanisms.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025Review
- Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium.Regulatory toxicology and pharmacology : RTP · 2024Article
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024Article
- Kratom safety and toxicology in the public health context: research needs to better inform regulation.Frontiers in pharmacology · 2024Review
- Hepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants.Frontiers in nutrition · 2024Article
- Unexpected Drug-Induced Liver Injury Associated With MenoFit: A Synbiotic Menopause Supplement.ACG case reports journal · 2023Article
- Everyday Evaluation of Herb/Dietary Supplement-Drug Interaction: A Pilot Study.Medicines (Basel, Switzerland) · 2023Article
- Cortical ribbon sign on neuroimaging in a patient with hepatic encephalopathy secondary to herbal medicine usage.Einstein (Sao Paulo, Brazil) · 2023Article
- A comprehensive update in herbal and dietary supplement-induced liver injury.Clinical liver diseaseArticle
- A Case of Abnormal Liver Function Tests in a Patient Receiving Total Parenteral Nutrition.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dietary supplements (DS) constitute a widely used group of products comprising vitamin, mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) comprise nearly 30% of all DS and are presented on the market either as single plant extracts or multi-extract-containing products. Despite generally safe toxicological profiles of most products currently present on the market, rising cases of liver injury caused by HDS - mostly by multi-ingredient and adulterated products - are of particular concern. Here we discuss the most prominent historical cases of HDS-induced hepatotoxicty - from Ephedra to Hydroxycut and OxyELITE Pro-NF, as well as products with suspected hepatotoxicity that are either currently on or are entering the market. We further provide discussion on overcoming the existing challenges with HDS-linked hepatotoxicity by introduction of advanced in silico, in vitro, in vivo, and microphysiological system approaches to address the matter of safety of those products before they reach the market.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.