Evidence map›Paper›PMID 36183780›Full record

ReviewLife sciences2022

Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality.

Aneta Aleksova, Alessandra Lucia Fluca, Giulia Gagno, Alessandro Pierri, Laura Padoan, Agnese Derin, Rita Moretti, Elena Aleksova Noveska, Eros Azzalini, Stefano D'Errico and 5 more

Open access · greenAbstract readReview
In one paragraph

Review in Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  8. Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeClCellular and molecular life sciences : CMLS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Aneta AleksovaAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy. Electronic address: aaleksova@units.it.
Alessandra Lucia FlucaAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Giulia GagnoAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Alessandro PierriAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Laura PadoanDepartment of Cardiology and Cardiovascular Physiopathology, Università degli Studi di Perugia, Perugia, Italy.
Agnese DerinAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy.
Rita MorettiDepartment of Internal Medicine and Neurology, Neurological Clinic, University of Trieste, Trieste, Italy.
Elena Aleksova NoveskaDepartment of Pediatric and Preventive Dentistry, Faculty of Dental Medicine, Ss. Cyril and Methodius University, Skopje, Macedonia.
Eros AzzaliniDepartment of Medical Sciences (DSM), University of Trieste, Trieste, Italy.
Stefano D'ErricoDepartment of Medicine, Surgery and Health, University of Trieste, Trieste, Italy.
Antonio Paolo BeltramiDepartment of Medicine (DAME), University of Udine, Udine, Italy.
Alimuddin ZumlaDepartment of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, UK; National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, UK.
Giuseppe IppolitoItalian Ministry of Health, Rome, Italy.
Gianfranco SinagraAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Milijana JanjusevicAzienda Sanitaria Universitaria Giuliano Isontina, Cardiothoracovascular Department, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Azienda Sanitaria Universitaria Integrata di Trieste · ITUniversity of Trieste · ITMinistero della Salute · ITNational Institute for Health Research · GBSaints Cyril and Methodius University of Skopje · MKUniversity of Perugia · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early 2020, it was evident that patients with cardiovascular disease (CVD) were at an increased risk of developing severe illness, and complications spanning cerebrovascular disorders, dysrhythmias, acute coronary syndrome, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure, thromboembolic disease, stroke, and death. Underlying these was excessive systemic inflammation and coagulopathy due to SARS-COV-2 infection, the effects of which also continued long-term as evidenced by post-COVID-19 cardiovascular complications. The acute and chronic cardiovascular effects of COVID-19 occurred even among those who were not hospitalized and had no previous CVD or those with mild symptoms. This comprehensive review summarizes the current understanding of molecular mechanisms triggered by the SARS-CoV-2 virus on various cells that express the angiotensin-converting enzyme 2, leading to endothelial dysfunction, inflammation, myocarditis, impaired coagulation, myocardial infarction, arrhythmia and a multisystem inflammatory syndrome in children or Kawasaki-like disease.

Indexed as

Cardiovascular DiseasesCOVID-19MyocarditisChildHumansInflammationSARS-CoV-2Systemic Inflammatory Response SyndromeCOVID-19Endothelial dysfunctionInflammationMyocardial injuryOxidative stressThrombosis

Identifiers

PMID36183780
PMCPMC9561478
OpenAlexW4298009025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.