Evidence map›Paper›PMID 36183751›Full record

ArticleGastroenterology2023

Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients.

Heather K Armstrong, Michael Bording-Jorgensen, Deanna M Santer, Zhengxiao Zhang, Rosica Valcheva, Aja M Rieger, Justin Sung-Ho Kim, Stephanie I Dijk, Ramsha Mahmood, Olamide Ogungbola and 23 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02865707 (Prevention of Ulcerative Colitis by Prebiotics), which is not on this map. Cited by 109 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02865707 nacompletednot on this map

Prevention of Ulcerative Colitis by Prebiotics: Efficacy and Protective Mechanisms

TypeinterventionalSponsorUniversity of AlbertaRan2016 to 2020Enrolled89ConditionsUlcerative ColitisArmsSynergy-1, Maltodextrin
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.

  1. Guideline
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  5. Article
  6. Inflammatory bowel disease is a conundrum.Chinese medical journal · 2026
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 6 institutions in 4 countries.

Heather K ArmstrongCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: Heather.Armstrong@umanitoba.ca.
Michael Bording-JorgensenCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Deanna M SanterDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Zhengxiao ZhangCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada; College of Food and Biological Engineering, Jimei University, Xiamen, Fujian, China.
Rosica ValchevaCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Aja M RiegerDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Justin Sung-Ho KimDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada; Department of Physics, University of Toronto, Toronto, Ontario, Canada.
Stephanie I DijkCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Ramsha MahmoodDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Olamide OgungbolaDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Juan JovelCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada.
France MoreauDepartment of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, Alberta, Canada.
Hayley GormanDepartment of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, Alberta, Canada.
Robyn DicknerCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Jeremy JerasiCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Inderdeep K ManderCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Dawson LafleurCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Christopher ChengCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Alexandra PetrovaDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Terri-Lyn JeansonDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Andrew MasonCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Consolato M SergiAnatomic Pathology Division, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Arie LevinePediatric Gastroenterology Unit, Wolfson Medical Center, Tel-Aviv University, Holon, Israel.
Kris ChadeeDepartment of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, Alberta, Canada.
David ArmstrongDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Sarah RauscherDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada; Department of Physics, University of Toronto, Toronto, Ontario, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Charles N BernsteinDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Matthew W CarrollDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Hien Q HuynhDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Jens WalterCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; APC Microbiome Ireland, School of Microbiology, and Department of Medicine, University College Cork, Cork, Ireland.
Karen L MadsenCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Levinus A DielemanCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Eytan WineCentre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Department of Physiology, University of Alberta, Edmonton, Alberta, Canada. Electronic address: wine@ualberta.ca.
University of Alberta · CAUniversity of Manitoba · CAUniversity of Calgary · CAUniversity of Toronto · CAChildren's Hospital of Eastern Ontario · CATel Aviv University · IL

Funding

CIHR
6 · The paper itself

Abstract

BACKGROUND &

aimsInflammatory bowel diseases (IBD) are affected by dietary factors, including nondigestible carbohydrates (fibers), which are fermented by colonic microbes. Fibers are overall beneficial, but not all fibers are alike, and some patients with IBD report intolerance to fiber consumption. Given reproducible evidence of reduced fiber-fermenting microbes in patients with IBD, we hypothesized that fibers remain intact in select patients with reduced fiber-fermenting microbes and can then bind host cell receptors, subsequently promoting gut inflammation.

methodsColonic biopsies cultured ex vivo and cell lines in vitro were incubated with oligofructose (5 g/L), or fermentation supernatants (24-hour anaerobic fermentation) and immune responses (cytokine secretion [enzyme-linked immunosorbent assay/meso scale discovery] and expression [quantitative polymerase chain reaction]) were assessed. Influence of microbiota in mediating host response was examined and taxonomic classification of microbiota was conducted with Kraken2 and metabolic profiling by HUMAnN2, using R software.

resultsUnfermented dietary β-fructan fibers induced proinflammatory cytokines in a subset of IBD intestinal biopsies cultured ex vivo, and immune cells (including peripheral blood mononuclear cells). Results were validated in an adult IBD randomized controlled trial examining β-fructan supplementation. The proinflammatory response to intact β-fructan required activation of the NLRP3 and TLR2 pathways. Fermentation of β-fructans by human gut whole microbiota cultures reduced the proinflammatory response, but only when microbes were collected from patients without IBD or patients with inactive IBD. Fiber-induced immune responses correlated with microbe functions, luminal metabolites, and dietary fiber avoidance.

conclusionAlthough fibers are typically beneficial in individuals with normal microbial fermentative potential, some dietary fibers have detrimental effects in select patients with active IBD who lack fermentative microbe activities. The study is publicly accessible at the U.S. National Institutes of Health database (clinicaltrials.gov identification number NCT02865707).

Indexed as

FructansInflammatory Bowel DiseasesAdultDietary FiberHumansInflammationIntestinesLeukocytes, MononuclearDietary FiberFructansDietary FibersFermentationIBDMicrobiome

Identifiers

PMID36183751
OpenAlexW4297980315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.