Evidence map›Paper›PMID 36183712›Full record

ReviewThe Lancet. Neurology2022

Traumatic brain injury: progress and challenges in prevention, clinical care, and research.

Andrew I R Maas, David K Menon, Geoffrey T Manley, Mathew Abrams, Cecilia Åkerlund, Nada Andelic, Marcel Aries, Tom Bashford, Michael J Bell, Yelena G Bodien and 92 more

Erratum issued 6 registry-linked trialsAbstract readReview
In one paragraph

Review in The Lancet. Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 6 registered trials, which are not on this map. Cited by 830 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
830citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06163833 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

MATRIx: MesenchymAl Stromal Cells for Traumatic bRain Injury

TypeinterventionalSponsorFondazione IRCCS San Gerardo dei TintoriRan2023 to 2026Enrolled78ConditionsTraumatic Brain Injury With Loss of ConsciousnessArmsMesenchymal stromal cell low dosage-80*10^6 cells, Mesenchymal stromal cell low dosage-160*10^6 cells, Placebo-storage solution
NCT06515132 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy and Safety of Spinal Cord Stimulation in Patients With Disorders of Consciousness: A Multicenter, Double-blind, Randomized Controlled Trail

TypeinterventionalSponsorHuashan HospitalRan2025 to 2026Enrolled50ConditionsDisorder of Consciousness, Spinal Cord StimulationArmsSCS Stimulation, Sham Stimulation
NCT06537713 completednot on this map

Diagnostic Role of Serum Testican and Ubiquitin Levels in Patients With Head Trauma

TypeobservationalSponsorKanuni Sultan Suleyman Training and Research HospitalRan2020 to 2021Enrolled89ConditionsModerate Traumatic Brain Injury, Testican-1, UbiquitinArmsTestican-1
NCT06816199 recruitingnot on this mapstarted 2025, after this paper: background citation

A Prospective Cohort Study Exploring the Safety and the Efficiency of Hyperbaric Oxygen in Treating Traumatic Brain Injury During Nonacute Phrase

Typeobservational_patient_registrySponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2025 to 2030Enrolled300ConditionsTraumatic Brain InjuryArmsHyperbaric oxygen exposure
NCT06927063 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury

Typeobservational_patient_registrySponsorTurku University HospitalRan2025 to 2028Enrolled160ConditionsTraumatic Brain InjuryArmsblood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain), Structural magnetic resonance imaging (brain), PET imaging (brain)
NCT07702513 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Randomized Waitlist-Controlled Study of Home-Based Rhythmic Auditory Stimulation to Evaluate Mobility, Balance, and Patient-Reported Outcomes After Traumatic Brain Injury

TypeinterventionalSponsorCraig HospitalRan2026 to 2028Enrolled33ConditionsTraumatic Brain Injury, Traumatic Brain Injury, Patient, TBIArmsHome-Based Rhythmic Auditory Stimulation
3 · Its place in the literature

Who cites it

830 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Severe traumatic brain injury and long-term survival: a meta-analysis on life expectancy and mortality trends.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Nanozyme-based therapeutic strategies for traumatic brain injury.International journal of pharmaceutics: X · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

770 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

102 authors.

Andrew I R Maas
David K Menon
Geoffrey T Manley
Mathew Abrams
Cecilia Åkerlund
Nada Andelic
Marcel Aries
Tom Bashford
Michael J Bell
Yelena G Bodien
Benjamin L Brett
András Büki
Randall M Chesnut
Giuseppe Citerio
David Clark
Betony Clasby
D Jamie Cooper
Endre Czeiter
Marek Czosnyka
Kristen Dams-O'Connor
Véronique De Keyser
Ramon Diaz-Arrastia
Ari Ercole
Thomas A van Essen
Éanna Falvey
Adam R Ferguson
Anthony Figaji
Melinda Fitzgerald
Brandon Foreman
Dashiell Gantner
Guoyi Gao
Joseph Giacino
Benjamin Gravesteijn
Fabian Guiza
Deepak Gupta
Mark Gurnell
Juanita A Haagsma
Flora M Hammond
Gregory Hawryluk
Peter Hutchinson
Mathieu van der Jagt
Sonia Jain
Swati Jain
Ji-Yao Jiang
Hope Kent
Angelos Kolias
Erwin J O Kompanje
Fiona Lecky
Hester F Lingsma
Marc Maegele
Marek Majdan
Amy Markowitz
Michael McCrea
Geert Meyfroidt
Ana Mikolić
Stefania Mondello
Pratik Mukherjee
David Nelson
Lindsay D Nelson
Virginia Newcombe
David Okonkwo
Matej Orešič
Wilco Peul
Dana Pisică
Suzanne Polinder
Jennie Ponsford
Louis Puybasset
Rahul Raj
Chiara Robba
Cecilie Røe
Jonathan Rosand
Peter Schueler
David J Sharp
Peter Smielewski
Murray B Stein
Nicole von Steinbüchel
William Stewart
Ewout W Steyerberg
Nino Stocchetti
Nancy Temkin
Olli Tenovuo
Alice Theadom
Ilias Thomas
Abel Torres Espin
Alexis F Turgeon
Andreas Unterberg
Dominique Van Praag
Ernest van Veen
Jan Verheyden
Thijs Vande Vyvere
Kevin K W Wang
Eveline J A Wiegers
W Huw Williams
Lindsay Wilson
Stephen R Wisniewski
Alexander Younsi
John K Yue
Esther L Yuh
Frederick A Zeiler
Marina Zeldovich
Roger Zemek
InTBIR Participants and Investigators

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
ACL HHS 90DPTB0011NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain Injuries, TraumaticCost of IllnessHumansSportsViolence

Identifiers

PMID36183712
PMCPMC10427240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.