ReviewPsychiatry and clinical neurosciences2022
Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment.
Review in Psychiatry and clinical neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors and risk factors for suicide in late-life depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Joint Association of Functional Impairment and Depression with Advanced Cardiovascular-Kidney-Metabolic Syndrome: A Cross-Sectional and Cohort Study Using Two Large Datasets.Healthcare (Basel, Switzerland) · 2026Article
- Neuromodulation and cognition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prevalence and associated factors of cognitive impairment among hospitalized older adults with depression: a cross-sectional study from a tertiary psychiatric hospital in Guangzhou, China.Frontiers in public health · 2026Article
- Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Systematized delusions in a patient with covert hepatic encephalopathy: A clinicopathological insight into prodromal dementia with Lewy bodies.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Evolution of strategic framework of policies related to dementia care and prevention in China from 2000 to 2024.The Lancet regional health. Western Pacific · 2025Article
- Relationship Between Depression and Neurodegeneration: Risk Factor, Prodrome, Consequence, or Something Else? A Scoping Review.Biomedicines · 2025Review
- Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review.Brain sciences · 2024Review
- Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD).Scientific reports · 2024Article
- Ginsenoside Rg1 in neurological diseases: From bench to bedside.Acta pharmacologica Sinica · 2023Review
- Article
- Aberrant Expression of GABA-Related Genes in the Hippocampus of 3xTg-AD Model Mice from the Early to End Stages of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Case Report: Depression × dementia with Lewy bodies in the elderly: The importance of differential diagnosis.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Senile depression (SD) is a heterogeneous syndrome. Several clinical profiles are more likely to appear in SD than in early-life depression, but it remains unclear whether the pathophysiology is different. The prevalence of dementia increases with aging, and the underlying pathophysiological processes in the preclinical phase begin even before cognitive deficits or neurological signs appear. SD may be either a risk factor for developing dementia or a prodromal stage of dementia. The inconsistent findings regarding the association between SD and incident dementia may be attributable to the neuropathological heterogeneity underlying SD. Most studies have focused on patients with the clinical diagnosis of Alzheimer disease (AD) as an outcome, but several clinicopathological studies suggest that primary age-related tauopathy and argyrophilic grain disease may account for a proportion of cases clinically misdiagnosed as AD in the elderly population. Furthermore, most AD cases have additional neuropathologic changes such as cerebrovascular disease and Lewy body disease. Here, we review the neuropathological findings linking SD to incident dementia, focusing on common age-related neuropathologies. In particular, the roles of disturbance of neural circuity, imbalance of monoaminergic systems, dysregulation of the hypothalamic-pituitary-adrenal axis, and elevated neuroinflammatory status are discussed. Finally, we review the current treatment of SD in the context of age-related neuropathological changes.
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