ArticleGenes and immunity2022
Identification of an 11 immune-related gene signature as the novel biomarker for acute myocardial infarction diagnosis.
Article in Genes and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrative transcriptomic analysis identifies an oxidative stress-associated diagnostic signature for myocardial infarction.Journal of thrombosis and thrombolysis · 2026Article
- Machine learning-derived identification of an obesity and lipid metabolism-related genes signature for the diagnosis and molecular typing of acute myocardial infarction.Frontiers in cardiovascular medicine · 2026Article
- The Dual Role of ADAMTS1 in Cardiovascular Remodeling: Balancing Extracellular Matrix Homeostasis and Pathological States.Journal of cardiovascular development and disease · 2025Review
- Transcriptomic and Proteomic Insights into 6PPD/6PPD-Q Induced Oxidative Stress in Black-Spotted Frogs.Antioxidants (Basel, Switzerland) · 2025Article
- Astragaloside IV increases PDHA1 in mesenchymal stem cell exosomes to treat myocardial infarction.Scientific reports · 2025Article
- The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction.Journal of cardiothoracic surgery · 2025Article
- Pyroptosis-Related Molecular Clusters and Immune Infiltration in Pediatric Sepsis.Pediatric health, medicine and therapeutics · 2025Article
- Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects.Journal of inflammation research · 2025Article
- Expression characteristics of lipid metabolism-related genes and correlative immune infiltration landscape in acute myocardial infarction.Scientific reports · 2024Article
- Comprehensive bioinformatics analytics andAging · 2024Article
- Immune response stability to the SARS-CoV-2 mRNA vaccine booster is influenced by differential splicing of HLA genes.Scientific reports · 2024Article
- Potential diagnostic biomarkers: 6 cuproptosis- and ferroptosis-related genes linking immune infiltration in acute myocardial infarction.Genes and immunity · 2023Article
- Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics.Journal of inflammation research · 2023Article
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3 authors.
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Abstract
This study explored the valuable immune gene signature for diagnosis of acute myocardial infarction (AMI). Three training gene expression datasets (GSE48060, GSE34198, and GSE97320) and one validation dataset (GSE109048) were downloaded from GEO database. The differentially infiltrated immune cells were analyzed by CIBERSORT. The immune genes were screened by WGCNA with differential immune cells as phenotype. Differentially expressed genes were analyzed in training datasets, followed by differential immune gene identification. The immune genes with diagnostic value were filtered by univariate regression analysis and LASSO model construction. ROC curve evaluated the diagnostic value of this model. A total of 304 differential immune genes were obtained, which were closely related to immune response-related pathways. An 11-gene signature (ADAMTS1, CNN2, DHRS13, DUSP1, FASLG, GNPTAB, NARF, PHC2, RAB7A, VNN3, and YIPF3) was filtered to be diagnostic biomarker for AMI (AUC = 0.805) and validated in GSE109048 dataset (AUC = 0.608). Based on the diagnostic model, high- and low-risk groups showed ten differential immune cells (such as T cells gamma delta, Macrophages M0, and Neutrophils) and differentially activated immune pathways (such as Antigen_Processing_and_Presentation and Cytokine_Receptors). PHC2 showed the highest positive correlation with Neutrophils and Cytokine_Receptors. The 11-gene signature could be served as a novel biomarker for the presence of AMI.
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