Evidence map›Paper›PMID 36182926›Full record

SynthesisEuropean journal of medical research2022

Point-of-care platelet function testing for guided transfusion in neurosurgical management of intracranial hemorrhage: a systematic review.

Flora Wen Xin Xu, Nicole-Ann Lim, Ming Ann Sim, Lyn Li Lean, Ne-Hooi Will Loh, Ka Ting Ng, Vanessa Tze Yuh Chua, Sophia Tsong Huey Chew, Lian Kah Ti

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. Recent advances in perioperative blood management.Indian journal of anaesthesia · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Flora Wen Xin Xu *Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Nicole-Ann Lim *Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ming Ann SimDepartment of Anesthesia, Singapore General Hospital, Singapore, Singapore.
Lyn Li LeanDepartment of Anesthesia, Ng Teng Fong General Hospital, Singapore, Singapore.
Ne-Hooi Will LohDepartment of Anesthesia, National University Hospital, Singapore, Singapore.
Ka Ting NgDepartment of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Vanessa Tze Yuh ChuaDepartment of Anesthesia, Singapore General Hospital, Singapore, Singapore.
Sophia Tsong Huey ChewDepartment of Anesthesia, Singapore General Hospital, Singapore, Singapore.
Lian Kah TiDepartment of Anesthesia, National University Hospital, Singapore, Singapore. lian_kah_ti@nuhs.edu.sg.
National University Hospital · SGNational University of Singapore · SGSingapore General Hospital · SGNg Teng Fong General Hospital · SGUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the rising prevalence of antiplatelet therapy, rapid preoperative identification of patients with bleeding diathesis is necessary for the guidance of blood product administration. This is especially relevant in neurosurgery for intracranial hemorrhage (ICH), where indiscriminate transfusions may lead to further hemorrhagic or thromboembolic injury. Point-of-care (POC) testing of platelet function is a promising solution to this dilemma, as it has been proven effective in cardiac surgery. However, to date, POC platelet function testing in neurosurgery has not been extensively evaluated. This systematic review appraises the use of POC platelet function test (PFT) in emergency neurosurgery in terms of its impact on patient outcomes.A comprehensive search was conducted on four electronic databases (Pubmed, MEDLINE, Embase, and Cochrane) for relevant English language articles from their respective inceptions until 1 June 2022. We included all randomized controlled trials and cohort studies that met the following inclusion criteria: (i) involved adult patients undergoing neurosurgery for ICH; (ii) evaluated platelet function via POC PFT; (iii) reported a change in perioperative blood loss; and/or (iv) reported data on treatment-related adverse events and mortality. Assessment of study quality was conducted using the Newcastle Ottawa Quality Assessment Scale for Cohort Studies and Case-Control Studies, and the JBI Critical Appraisal Checklist for Case Series.The search yielded 2,835 studies, of which seven observational studies comprising 849 patients met the inclusion criteria for this review. Overall, there is evidence that the use of POC PFT to assess bleeding risk reduced bleeding events, thromboembolic adverse outcomes, and the length of hospitalization. However, there is currently insufficient evidence to suggest that using POC PFT improves blood product use, functional outcomes or mortality.

Indexed as

Platelet Aggregation InhibitorsPoint-of-Care SystemsAdultHemorrhageHumansIntracranial HemorrhagesPlatelet Function TestsPlatelet Aggregation InhibitorsNeurosurgeryPerioperative carePlatelet functionPoint-of-care test

Identifiers

PMID36182926
PMCPMC9526957
OpenAlexW4298616656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.