Evidence map›Paper›PMID 36182780›Full record

ArticleClinical neurology and neurosurgery2022

Treatment selection towards active surveillance over definitive treatment for pituitary adenomas is influenced by sociodemographic factors.

Brandon M Lehrich, Jack L Birkenbeuel, Kelsey Roman, Amin Mahmoodi, Khodayar Goshtasbi, Ronald Sahyouni, Frank P K Hsu, Edward C Kuan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurology and neurosurgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Brandon M LehrichMedical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA.
Jack L BirkenbeuelDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Kelsey RomanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Amin MahmoodiMedical Scientist Training Program, University of California, San Diego, CA, USA.
Khodayar GoshtasbiDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Ronald SahyouniDepartment of Neurosurgery, University of California, San Diego, CA, USA.
Frank P K HsuDepartment of Neurological Surgery, University of California, Irvine, CA, USA.
Edward C KuanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA; Department of Neurological Surgery, University of California, Irvine, CA, USA. Electronic address: eckuan@uci.edu.
University of California, Irvine · USUniversity of California, San Diego · USNeurological Surgery · USUniversity of Pittsburgh Medical Center · US

Funding

TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
NIGMS NIH HHS T32 GM008208
6 · The paper itself

Abstract

backgroundClinical and sociodemographic predictors of pituitary adenoma (PA) patients undergoing active surveillance (AS) versus definitive treatment (DT) are poorly understood.

objectiveThis population-based analysis aims to identify clinical and sociodemographic predictors of undergoing AS versus DT.

methodsThe National Cancer Database (NCDB) was utilized to query PA patients diagnosed from 2010 to 2015 undergoing AS or DT. Independent-samples t-test and chi-squared test were used to compare differences in patient baseline characteristics and a stepwise binary logistic regression was performed to elucidate factors implicated in undergoing AS.

resultsThe cohort consisted of 30,233 PA patients, with 5147 (17.0%) patients undergoing AS. On multivariable logistic regression, patients aged ≥ 65 years (OR=1.65; p < 0.001), African American race (OR=1.12; p = 0.035), having government insurance (OR=1.45; p < 0.001) or those uninsured (OR=1.58; p < 0.001) were significantly more likely to undergo AS compared to DT, while patients with larger tumors (OR=0.90; p < 0.001), receiving treatment at academic facilities (OR=0.75; p < 0.001), and living in West regions of the United States (OR=0.59; p < 0.001) were significantly less likely to undergo AS compared to DT.

conclusionsSignificant sociodemographic disparities exist in patient selection for undergoing AS versus DT, which may modify patient clinical outcomes.

Indexed as

AdenomaPituitary NeoplasmsHumansPatient SelectionSociodemographic FactorsUnited StatesWatchful WaitingActive surveillanceConservative managementPituitary adenomaSurgeryWatchful waiting

Identifiers

PMID36182780
PMCPMC12857114
OpenAlexW4297398289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.