ArticleThe journal of allergy and clinical immunology. In practice2022
Penicillin Allergy Label Is Associated With Worse Clinical Outcomes in Bacterial Pneumonia.
Article in The journal of allergy and clinical immunology. In practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- The Pragmatic Removal of Penicillin Allergy Electronic Health Record Labels (PROPEL) Trial: A Randomized Clinical Trial.The journal of allergy and clinical immunology. In practice · 2025Trial
- Randomized Multicenter Trial for the Validation of an Easy-to-Administer Algorithm to Define Penicillin Allergy Status in Sexually Transmitted Infection Clinic Outpatients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Association of a Reported Penicillin Allergy Label With Clinical Outcomes in Alcohol-Associated Liver Disease.Alcohol, clinical & experimental research · 2026Article
- Penicillin Allergy Labels and High-risk Antibiotic Prescribing Among Incarcerated Individuals Receiving Antibiotics Across Four US Carceral Systems.Open forum infectious diseases · 2026Article
- Penicillin Allergy Labels, Broad-Spectrum Antibiotic Use, and Chronic Obstructive Pulmonary Disease Exacerbations: A Population-Based Cohort Study from China.Infection and drug resistance · 2026Article
- Sex-based differences in penicillin allergy labeling among adults in a Canadian ambulatory urgent medicine clinic: a cross-sectional study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Evaluation of the Allergy Fact Checker, a clinical decision support system for non-invasive beta-lactam delabeling: a mixed-methods study.NPJ digital medicine · 2025Article
- Reported penicillin allergy in Israel: Clinical outcomes and antibiotic costs in a nationwide population-based cohort study.The journal of allergy and clinical immunology. Global · 2025Article
- Single-Shot Perioperative Antibiotic Prophylaxis in Patients With a History of Penicillin Allergy: An Algorithm for the Safe Administration of Cefuroxime.Deutsches Arzteblatt international · 2025Observational
- Impact of sulfonamide allergy label on clinical outcomes of acute cystitis: a retrospective matched cohort study.Internal medicine journal · 2025Article
- Resensitization-Should Repeat Testing Be Performed in Patients Undergoing Penicillin Allergy Evaluations? A Pro-Con Debate.The journal of allergy and clinical immunology. In practice · 2025Review
- Rationalizing antibiotic prescribing for bacterial pneumonia in patients with reported penicillin allergy-a qualitative study.JAC-antimicrobial resistance · 2025Article
- Impact of beta-lactam allergy labels on bone marrow transplant patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Sulfonamide allergy label and the risk of opportunistic infections in solid organ transplant recipients - A retrospective matched cohort study.Transplant infectious disease : an official journal of the Transplantation Society · 2024Article
- A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions.Transplant infectious disease : an official journal of the Transplantation Society · 2024Review
- Narrative review of recent developments and the future of penicillin allergy de-labelling by non-allergists.npj antimicrobials and resistance · 2024Review
- Impact of Sulfonamide Allergy Label on Clinical Outcomes in Patients with Pneumocystis jirovecii Pneumonia.Pulmonary therapy · 2024Article
- Examining Antimicrobial Stewardship Program Implementation in Carceral Settings.AMA journal of ethics · 2024Article
- Not a Benign (Mis)Label: Penicillin Allergy Education for the Nonallergist.MedEdPORTAL : the journal of teaching and learning resources · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPenicillins (PCNs) are a first-line treatment option for bacterial pneumonia. PCN allergy label can delay antimicrobial treatment and result in the use of alternative antibiotic regimens risking an inadequate response to treatment and potentially increased adverse drug reactions.
objectiveTo investigate the impact of PCN allergy label on clinical outcomes of bacterial pneumonia.
methodsThis retrospective cohort study used TriNetX, a web-based tool for population cohort research, to identify adult patients with and without PCN allergy label diagnosed with bacterial pneumonia. Cohorts were matched for baseline demographics and chronic medical conditions. The 30-day risks of hospitalization, acute respiratory failure, intubation, need for intensive level of care, and mortality were compared. Antibiotics used and their possible adverse reactions were explored.
resultsAfter matching, there were 68,748 patients in each cohort. Patients with bacterial pneumonia with PCN allergy label had higher risks of hospitalization (risk ratio [RR], 1.23; 95% confidence interval [CI], 1.22-1.24), acute respiratory failure (RR, 1.14; 95% CI, 1.12-1.15), intubation (RR, 1.18; 95% CI, 1.13-1.22), intensive level of care (RR, 1.11; 95% CI, 1.08-1.14), and mortality (RR, 1.08; 95% CI, 1.04-1.13) compared with patients without PCN allergy label. Patients with PCN allergy label had decreased use of PCNs and cephalosporins and increased utilization of other antibiotic classes compared with patients without PCN allergy label. PCN allergy label was also associated with increased risk of adverse drug reactions.
conclusionPCN allergy label is associated with worse clinical outcomes in bacterial pneumonia, and risk mitigation strategies should be considered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.