Evidence map›Paper›PMID 36181875›Full record

ArticleJournal of pharmaceutical sciences2023

Radio Frequency - Assisted Ultrasonic Spray Freeze Drying for Pharmaceutical Protein Solids.

Tarun Tejasvi Mutukuri, Ahmad Darwish, Andrew David Strongrich, Dimitrios Peroulis, Alina Alexeenko, Qi Tony Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tarun Tejasvi MutukuriDepartment of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.
Ahmad DarwishElmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Andrew David StrongrichBirck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA; Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Dimitrios PeroulisElmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907, USA; Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA.
Alina AlexeenkoDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA; School of Aeronautics and Astronautics, Purdue University, West Lafayette, Indiana 47907, USA.
Qi Tony ZhouDepartment of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA. Electronic address: tonyzhou@purdue.edu.
Purdue University West Lafayette · US

Funding

Advancing innovative therapies against pandrug-resistant Gram-negative superbugsR01AI146160 · NIAID · PURDUE UNIVERSITY · PI LI, JIAN, ZHOU, QI · 2019 to 2023
$3.2M
NIAID NIH HHS R01 AI146160
6 · The paper itself

Abstract

This study examined physical stability of spray freeze dried (SFD) bovine serum albumin (BSA) solids produced using the radio frequency (RF)-assisted drying technique. BSA formulations were prepared with varying concentrations of trehalose and mannitol, using an excipient-free formulation as control. These formulations were produced using either traditional ultrasonic spray freeze drying (SFD) or RF-assisted ultrasonic spray freeze drying (RFSFD). The dried formulations were then characterized using Karl Fischer moisture content measurement, powder X-ray diffraction (PXRD), size exclusion chromatography (SEC), and solid-state hydrogen/deuterium exchange with mass spectrometry (ssHDX-MS). Moisture content did not have a good correlation with the physical stability of the formulations measured by SEC. ssHDX-MS metrics such as deconvoluted peak areas of the deuterated samples showed a satisfactory correlation (R

Indexed as

TrehaloseUltrasonicsExcipientsFreeze DryingMannitolPowdersSerum Albumin, BovineExcipientsMannitolPowdersSerum Albumin, BovineTrehaloseBiopharmaceutical processingProtein structureRadio frequency spray freeze dryingSolid formulationSpray freeze drying

Identifiers

PMID36181875
PMCPMC9772299
OpenAlexW4297512928

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.