Evidence map›Paper›PMID 36181558›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2023

Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.

Clarissa Ribeiro Bastos, Bertha Bueno Bock, Janaina Xavier, Laísa Camerini, Samantha Seibt Dewes, Mateus Grellert, Hudson Wander de Carvalho, Karen Jansen, Ricardo Azevedo da Silva, Ricardo Tavares Pinheiro and 6 more

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Clarissa Ribeiro BastosPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Bertha Bueno BockPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Janaina XavierPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Laísa CameriniPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Samantha Seibt DewesPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Mateus GrellertFederal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Hudson Wander de CarvalhoDepartment of Psychology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Karen JansenPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Ricardo Azevedo da SilvaPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Ricardo Tavares PinheiroPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Luciano de Mattos SouzaPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil.
Jean Pierre OsesInstitute of Biological Sciences, Federal University of Rio Grande, Rio Grande, Rio Grande do Sul, Brazil.
Luis Valmor PortelaDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Diogo Rizzato LaraDepartment of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Luciana Tovo-RodriguesPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Gabriele GhisleniPost-Graduation Program in Health and Behavior, Center of Health Science, Catholic University of Pelotas, 373, 324C Gonçalves Chaves Street, Pelotas, Rio Grande do Sul, CEP 96015-560, Brazil. ghisleni.g@gmail.com.ORCID http://orcid.org/0000-0002-1764-6882
Universidade Católica de Pelotas · BRUniversidade Federal de Pelotas · BRPontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Federal de Santa Catarina · BRUniversidade Federal do Rio Grande · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

PRONEX-FAPERGS (08/2009 - PronexPRONEX-FAPERGS grant number 10/0055-0)
6 · The paper itself

Abstract

The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially genetically determined and seem to be influenced by variations in the CACNA1C gene. These variations presented a significant interactive effect with biological sex, although studies that evaluate this relationship are scarce. Here, we assessed the mediation effect of temperament traits on the relationship between two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) and BD according to sex. This is a cross-sectional study consisting of 878 Caucasian individuals (508 women and 370 men), aged 18-35, enrolled in a population-based study in the city of Pelotas, Southern Brazil. BD diagnosis was evaluated using the clinical interview MINI 5.0, and temperament traits were assessed via the application of the Affective and Emotional Composite Temperament Scale (AFECTS). Mediation models were tested using the modeling tool PROCESS (version 3.3) for SPSS. Bootstrapping-enhanced mediation analyses in women indicated that traits anger (39%) and caution (27%) mediated the association between the rs4765913 SNP and BD, while traits volition (29%), anger (35%), and caution (29%) mediated the association between the AA haplotype (rs1006737-rs4765913) and the BD. No effect was encountered for cisgender men. Our model revealed that paths from CACNA1C SNPs to BD are mediated by specific temperament traits in women, reinforcing the definition of temperament traits as endophenotypes.

Indexed as

Bipolar DisorderAdolescentAdultCalcium Channels, L-TypeCross-Sectional StudiesEmotionsFemaleHumansMalePolymorphism, Single NucleotideTemperamentYoung AdultCACNA1C protein, humanCalcium Channels, L-TypeAFECTSBipolar disorderCalcium channels L-typeSex differencesTemperament

Identifiers

PMID36181558
OpenAlexW4298327029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.