ArticleBrain : a journal of neurology2023
Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience.
Article in Brain : a journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 57 citations in OpenAlex.
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Network localization of brain structural and functional alterations induced by electroconvulsive therapy for depression.Translational psychiatry · 2026Article
- The many-to-many problem of endophenotypes in psychiatry - a biological perspective.Molecular psychiatry · 2026Review
- A clinical neuroimaging platform for rapid, automated lesion detection and personalized post-stroke outcome prediction.NPJ digital medicine · 2026Article
- Brain network representations of placebo analgesia.Psychological medicine · 2026Article
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Severity-dependent fronto-cingulate network compensation of immune-dependent caudate-insula dysconnectivity in bipolar II depression.Research square · 2026Article
- Network localization of brain functional effects of ketamine treatment for major depression.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Identification of Brain Regions and Networks Critical to Poststroke Cognitive Impairment Through Lesion-symptom and Lesion Network Analyses.Translational stroke research · 2026Article
- Lesions involving the insula are associated with reduced appetite and weight loss.Brain communications · 2026Article
- Unsupervised mapping of causal relations between brain lesions and behavior.bioRxiv : the preprint server for biology · 2025Article
- From brain to behavior: Psychological resilience mediates associations between whole-brain resting-state connectivity and NSSI.Dialogues in clinical neuroscience · 2025Article
- Brain Network Signature of Autoscopic Phenomena in Humans.CNS neuroscience & therapeutics · 2025Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Reduced mind-wandering and fewer depressive symptoms associated with damage to the medial prefrontal cortex and default mode network.Neuropsychologia · 2025Article
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- Network Localization of Pediatric Lesion-Induced Dystonia.Annals of neurology · 2025Article
- Article
- Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.PLoS biology · 2025Article
- Lesion and lesion network localization of dysnomia after epilepsy surgery.Brain : a journal of neurology · 2025Article
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6 authors at 2 institutions in 1 country.
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Abstract
Understanding neural circuits that support mood is a central goal of affective neuroscience, and improved understanding of the anatomy could inform more targeted interventions in mood disorders. Lesion studies provide a method of inferring the anatomical sites causally related to specific functions, including mood. Here, we performed a large-scale study evaluating the location of acquired, focal brain lesions in relation to symptoms of depression. Five hundred and twenty-six individuals participated in the study across two sites (356 male, average age 52.4 ± 14.5 years). Each subject had a focal brain lesion identified on structural imaging and an assessment of depression using the Beck Depression Inventory-II, both obtained in the chronic period post-lesion (>3 months). Multivariate lesion-symptom mapping was performed to identify lesion sites associated with higher or lower depression symptom burden, which we refer to as 'risk' versus 'resilience' regions. The brain networks and white matter tracts associated with peak regional findings were identified using functional and structural lesion network mapping, respectively. Lesion-symptom mapping identified brain regions significantly associated with both higher and lower depression severity (r = 0.11; P = 0.01). Peak 'risk' regions include the bilateral anterior insula, bilateral dorsolateral prefrontal cortex and left dorsomedial prefrontal cortex. Functional lesion network mapping demonstrated that these 'risk' regions localized to nodes of the salience network. Peak 'resilience' regions include the right orbitofrontal cortex, right medial prefrontal cortex and right inferolateral temporal cortex, nodes of the default mode network. Structural lesion network mapping implicated dorsal prefrontal white matter tracts as 'risk' tracts and ventral prefrontal white matter tracts as 'resilience' tracts, although the structural lesion network mapping findings did not survive correction for multiple comparisons. Taken together, these results demonstrate that lesions to specific nodes of the salience network and default mode network are associated with greater risk versus resiliency for depression symptoms in the setting of focal brain lesions.
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