ArticleAmerican journal of human biology : the official journal of the Human Biology Council2022
Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya.
Article in American journal of human biology : the official journal of the Human Biology Council, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Determinants of human milk lactoferrin concentrations in rural Bangladesh.PLOS global public health · 2026Article
- Day/night fluctuations of breast milk bioactive factors and microbiome.Frontiers in nutrition · 2025Article
- Colostrum Lactoferrin Following Active and Recovered SARS-CoV-2 Infections during Pregnancy.Biomedicines · 2024Article
- Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMilk lactoferrin is a multi-functional, iron-binding glycoprotein with immunomodulatory effects, protecting infants against infectious diseases.
aimsThis study explored how maternal inflammation/infection and iron-deficiency anemia (IDA) might influence human milk lactoferrin. Lactoferrin might be elevated with maternal inflammation resulting from infectious disease processes. Conversely, lactoferrin might decrease with IDA, corresponding to scarce maternal iron for transfer in milk. In these two hypothesized scenarios, the degree of lactoferrin elevation or decrease might vary with infant vulnerability to infectious diseases or malnutrition. Alternatively, lactoferrin might be unassociated with inflammation/infection or IDA if mothers could buffer it against these conditions. MATERIALS &
methodsWe used cross-sectional data from Ariaal mothers of northern Kenya (n = 200) to evaluate associations between milk lactoferrin and maternal inflammation/infection, IDA, infant age/sex, and the mother-infant variable interactions in multivariate regression models.
resultsMaternal inflammation was associated with higher lactoferrin for younger infants (<~5 months of age) but with lower lactoferrin for older infants. Maternal IDA was unassociated with lactoferrin alone or in interaction with infant variables. DISCUSSION &
conclusionResults suggest that mothers of vulnerable young infants deliver more lactoferrin when they have inflammation/infection but mothers with older infants do not, and that maternal delivery of lactoferrin is unaffected by their IDA. Longitudinal research should verify these findings.
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