Evidence map›Paper›PMID 36180920›Full record

ReviewEpigenetics & chromatin2022

A standardized nomenclature for mammalian histone genes.

Ruth L Seal, Paul Denny, Elspeth A Bruford, Anna K Gribkova, David Landsman, William F Marzluff, Monica McAndrews, Anna R Panchenko, Alexey K Shaytan, Paul B Talbert

Open access · goldAbstract readReview
In one paragraph

Review in Epigenetics & chromatin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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  19. Dietary effects on the retina of hamsters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Ruth L SealEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK. rseal@ebi.ac.uk.
Paul DennyEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
Elspeth A BrufordEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
Anna K GribkovaDepartment of Biology, Lomonosov Moscow State University, 119234, Moscow, Russia.
David LandsmanIntramural Research Program, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20892, USA.
William F MarzluffIntegrated Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, 27599, USA.
Monica McAndrewsMouse Genome Informatics, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Anna R PanchenkoDepartment of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, Ontario, Canada.
Alexey K ShaytanDepartment of Biology, Lomonosov Moscow State University, 119234, Moscow, Russia.
Paul B TalbertHoward Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA, 98109, USA.
European Bioinformatics Institute · GBLomonosov Moscow State University · RUHoward Hughes Medical Institute · USJackson Laboratory · USNational Institutes of Health · USQueen's University · CAUniversity of North Carolina at Chapel Hill · US

Funding

SOFTWARE AND DATABASE SYSTEM DEVELOPMENTP41HG000330 · NHGRI · JACKSON LABORATORY · PI EPPIG, JANAN T. · 1995 to 2010
$72.1M
Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human GenomeU24HG000330 · NHGRI · JACKSON LABORATORY · PI CAROL J BULT, Cynthia Louise Smith · 2021 to 2026
$20.5M
HISTONE MRNA REGULATION IN DEVELOPMENTR01GM058921 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MARZLUFF, WILLIAM F. · 1999 to 2025
$11.6M
CONTROL OF HISTONE MRNA SYNTHESISR01GM029832 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOMINSKI, ZBIGNIEW, MARZLUFF, WILLIAM F. · 1985 to 2022
$9.0M
The Nomenclature of Human and Vertebrate GenesU24HG003345 · NHGRI · UNIVERSITY OF CAMBRIDGE · PI Elspeth Bruford · 2018 to 2026
$3.9M
Howard Hughes Medical InstituteNHGRI NIH HHS P41 HG000330NHGRI NIH HHS U24 HG000330NHGRI NIH HHS U24 HG003345NIGMS NIH HHS R01 GM029832NIGMS NIH HHS R01 GM058921Wellcome TrustWellcome Trust 208349/Z/17/Z
6 · The paper itself

Abstract

Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resulted in agreement amongst experts on a revised systematic protein nomenclature for histones, which is based on a combination of phylogenetic classification and historical symbol usage. Human and mouse histone gene symbols previously followed a genome-centric system that was not applicable across all vertebrate species and did not reflect the systematic histone protein nomenclature. This prompted a collaboration between histone experts, the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) and Mouse Genomic Nomenclature Committee (MGNC) to revise human and mouse histone gene nomenclature aiming, where possible, to follow the new protein nomenclature whilst conforming to the guidelines for vertebrate gene naming. The updated nomenclature has also been applied to orthologous histone genes in chimpanzee, rhesus macaque, dog, cat, pig, horse and cattle, and can serve as a framework for naming other vertebrate histone genes in the future.

Indexed as

GenomicsHistonesAnimalsCattleDogsGenomeHorsesHumansMacaca mulattaMammalsMicePhylogenySwineHistones

Identifiers

PMID36180920
PMCPMC9526256
OpenAlexW4298326878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.