Evidence map›Paper›PMID 36180883›Full record

ArticleAlzheimer's research & therapy2022

Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APP

Jogender Mehla, Scott H Deibel, Hadil Karem, Shakhawat Hossain, Sean G Lacoursiere, Robert J Sutherland, Majid H Mohajerani, Robert J McDonald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jogender MehlaCanadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Scott H DeibelCanadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Hadil KaremCanadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Shakhawat HossainCanadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Sean G LacoursiereCanadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Robert J SutherlandCanadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Majid H Mohajerani *Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada. mohajerani@uleth.ca.
Robert J McDonald *Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada. r.mcdonald@uleth.ca.
University of Lethbridge · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn active lifestyle is associated with improved cognitive functions in aged people and may prevent or slow down the progression of various neurodegenerative diseases including Alzheimer's disease (AD). To investigate these protective effects, male APP

methodsThree-month-old AD mice were housed in a cage supplemented with a running wheel for 9 months for long-term exercise. At the age of 12 months, behavioral tests were completed for all groups. After completing behavioral testing, their brains were assessed for amyloid pathology, microgliosis, and cholinergic cells.

resultsThe results showed that APP

conclusionThese findings suggest the potential of physical exercise to mitigate the cognitive deficits in AD.

Indexed as

Alzheimer DiseaseAmyloidosisAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsAnxietyBrainCholinergic AgentsCognitionDisease Models, AnimalGene Knock-In TechniquesMaleMiceMice, TransgenicWaterAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCholinergic AgentsWaterAlzheimer diseaseAPPNL-G-F miceCholine acetyltransferaseCognitive dysfunctionMicrogliosisPhysical exercise

Identifiers

PMID36180883
PMCPMC9526288
OpenAlexW4298139055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.