SynthesisNature2022
Stroke genetics informs drug discovery and risk prediction across ancestries.
Erratum issued Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07553650 (Master Study Protocol for the Cohort of the Specialist Network Stroke), which is not on this map. Cited by 350 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 8 pooled it
101.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke) (Stroke-CORE)
Who cites it
350 citing papers in PubMed, 8 syntheses or guidelines pooled it, 569 citations in OpenAlex.
- Assessing the causal effects of environmental tobacco smoke exposure: a meta-analytic Mendelian randomization study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias.Nature genetics · 2026Pooled it
- Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Pooled it
- Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes.Genomics, proteomics & bioinformatics · 2025Pooled it
- Dissecting the Genetic Architecture of Intracranial Aneurysms.Circulation. Genomic and precision medicine · 2025Pooled it
- The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases.Communications biology · 2025Pooled it
- Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer.International journal of medical sciences · 2025Pooled it
- Identification ofDepression and anxiety · 2025Pooled it
- Polygenic Risk Identifies Older Adults Who May Benefit From Aspirin for the Primary Prevention of Ischemic Stroke.Stroke · 2026Trial
- Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.Renal failure · 2026Article
- Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study.Diabetes, obesity & metabolism · 2026Article
- Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data.Nature neuroscience · 2026Article
- Multimodal profiling of atherosclerosis: Protocol and pilot data for the AtherOMICS biobank.Science advances · 2026Article
- Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.Nature cardiovascular research · 2026Article
- Article
- Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization.medRxiv : the preprint server for health sciences · 2026Article
- Genetic Evidence That Stroke Causally Increases Circulating PDGFB Levels: a Two-Sample Mendelian Randomization Study.Journal of molecular neuroscience : MN · 2026Article
- Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.Nature aging · 2026Article
- Article
- TL-HDMR: a transfer learning framework for advancing equitable causal inference reveals metabolic signatures of stroke across multiple ancestries.Briefings in bioinformatics · 2026Article
290 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
202 authors at 20 institutions in 30 countries.
Aniket Mishra *Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.ORCID http://orcid.org/0000-0002-8141-1543
Rainer Malik *Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Tsuyoshi Hachiya *Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0002-5274-3266
Tuuli Jürgenson *Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Shinichi Namba *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID http://orcid.org/0000-0002-7486-3146
Daniel C Posner *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3056-6924
Frederick K KamanuTIMI Study Group, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7208-1047
Masaru KoidoDivision of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0348-0666
Quentin Le GrandBordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.ORCID http://orcid.org/0000-0002-9299-0747
Mingyang ShiLaboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Yunye HeLaboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8581-7826
Marios K GeorgakisInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-3507-3659
Ilana CaroBordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.ORCID http://orcid.org/0000-0003-3075-4682
Kristi KrebsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-0494-2751
Yi-Ching LiawLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4973-2777
Felix C VauraDepartment of Internal Medicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-6036-889X
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Bendik Slagsvold WinsvoldDepartment of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0003-4171-8919
Vinodh SrinivasasainagendraDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Livia ParodiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hee-Joon BaeDepartment of Neurology and Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Ganesh ChauhanRajendra Institute of Medical Sciences, Ranchi, India.
Michael R ChongThrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
Liisa TomppoDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-9369-5846
Rufus AkinyemiCenter for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Gennady V RoshchupkinDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3403-2313
Naomi HabibThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-6049-2487
Yon Ho JeeDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3484-9531
Vida AbediDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA.ORCID http://orcid.org/0000-0001-7689-933X
Jara Cárcel-MárquezStroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
Marianne NygaardThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-0703-2665
Hampton L LeonardCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2390-8110
Chaojie YangCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Ekaterina Yonova-DoingBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Maria J KnolDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3597-1531
Adam J LewisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Renae L JudyDepartment of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Tetsuro AgoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Philippe AmouyelUniversity of Lille, INSERM U1167, RID-AGE, LabEx DISTALZ, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Nicole D ArmstrongDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mark K BakkerUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7887-9014
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Constance BordesBordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.ORCID http://orcid.org/0000-0003-3367-1778
Sigrid BørteK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0001-9540-3256
Anael CainThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6423-105X
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
John W ColeVA Maryland Health Care System, Baltimore, MD, USA.
Phil L de JagerProgram in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8057-2505
Rafael de CidGenomesForLife-GCAT Lab Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.ORCID http://orcid.org/0000-0003-3579-6777
Matthias EndresKlinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-6520-3720
Leslie E FerreiraPost-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil.ORCID http://orcid.org/0000-0003-0276-9043
Mirjam I GeerlingsDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Natalie C GascaDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4790-3517
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Jun HataDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0003-2698-344X
Jing HeDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Alicia K HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6517-1300
Yuk-Lam HoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Aki S HavulinnaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4787-8959
Jemma C HopewellClinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Hyacinth I HyacinthDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Michael InouyeBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9413-6520
Mina A JacobDepartment of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Christina E JeonLos Angeles County Department of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7584-6228
Christina JernInstitute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Masahiro KamouchiDepartment of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Keith L KeeneDepartment of Biology, Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC, USA.ORCID http://orcid.org/0000-0002-7826-399X
Takanari KitazonoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Steven J KittnerDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Takahiro KonumaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Amit KumarRajendra Institute of Medical Sciences, Ranchi, India.ORCID http://orcid.org/0000-0003-0970-5333
Paul LacazeDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-0902-6798
Lenore J LaunerIntramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Keon-Joo LeeDepartment of Neurology, Korea University Guro Hospital, Seoul, Republic of Korea.
Kaido LepikEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-9884-3265
Jiang LiDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA.ORCID http://orcid.org/0000-0002-7006-1285
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.ORCID http://orcid.org/0000-0001-5873-7089
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-5998-795X
Hugh S MarkusStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Nicholas A MarstonTIMI Study Group, Boston, MA, USA.
Thomas MeitingerInstitute of Human Genetics, Technical University of Munich, Munich, Germany.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Felipe A MontellanoInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-9438-0854
Takayuki MorisakiDivision of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan.
Thomas H MosleyThe MIND Center, University of Mississippi Medical Center, Jackson, MS, USA.
Mike A NallsCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Børge G NordestgaardDepartment of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1954-7220
Martin J O'DonnellCollege of Medicine Nursing and Health Science, NUI Galway, Galway, Ireland.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID http://orcid.org/0000-0002-0311-8472
N Charlotte Onland-MoretDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bruce OvbiageleWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München,, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Jonathan RosandCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Marc S SabatineTIMI Study Group, Boston, MA, USA.
Ralph L SaccoDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Danish SaleheenDivision of Cardiology, Department of Medicine, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6193-020X
Else Charlotte SandsetStroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway.
Veikko SalomaaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Muralidharan SargurupremrajGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0003-1684-3750
Makoto SasakiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0002-3108-4361
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-1115-4430
Carsten O SchmidtUniversity Medicine Greifswald, Institute for Community Medicine, SHIP/KEF, Greifswald, Germany.
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0001-8307-2461
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Kelly L SloaneDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Yoichi SutohIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Yan V SunAtlanta VA Health Care System, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Kozo TannoIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0002-1264-0684
Steffen TiedtInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-8817-8457
Turgut TatlisumakDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Unviersity Hospital, Gothenburg, Sweden.
Nuria P Torres-AguilaStroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
Hemant K TiwariDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
David-Alexandre TrégouëtBordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-5006-0528
Anil Man TuladharDepartment of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Anne Tybjærg-HansenDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Marion van VugtDivision Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-6634-1989
Riina ViboDepartment of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-9138-3227
Shefali S VermaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2749-1279
Patrik WennbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Peter W F WilsonAtlanta VA Health Care System, Decatur, GA, USA.
Huichun XuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8118-9607
Qiong YangFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Kyungheon YoonDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea.ORCID http://orcid.org/0000-0001-6727-2789
COMPASS Consortium
INVENT Consortium
Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group
Estonian Biobank
PRECISE4Q Consortium
FinnGen Consortium
NINDS Stroke Genetics Network (SiGN)
MEGASTROKE Consortium
SIREN Consortium
China Kadoorie Biobank Collaborative Group
VA Million Veteran Program
International Stroke Genetics Consortium (ISGC)
Biobank Japan
CHARGE Consortium
GIGASTROKE Consortium
Iona Y MillwoodNuffield Department of Population Health, University of Oxford, Oxford, UK.
Christian GiegerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0003-1345-9032
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Ina L RissanenDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Daniel StrbianDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Young Jin KimDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea.ORCID http://orcid.org/0000-0002-4132-4437
Pei-Hsin ChenDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan.
Ernst MayerhoferCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8902-4209
Joanna M M HowsonBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7618-0050
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Hieab AdamsDepartment of Clinical Genetics, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Sylvia Wassertheil-SmollerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-5447-4653
Kaare ChristensenThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
Mohammad A IkramDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Tatjana RundekDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-7115-9815
Bradford B WorrallDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-9386-4091
G Mark LathropMcGill Genome Centre, Montreal, Quebec, Canada.
Moeen RiazDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Eleanor M SimonsickLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Janika KõrvDepartment of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-6074-0727
Paulo H C FrançaPost-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil.ORCID http://orcid.org/0000-0002-1750-9132
Ramin ZandGeisinger Neuroscience Institute, Geisinger Health System, Danville, PA, USA.
Kameshwar PrasadRajendra Institute of Medical Sciences, Ranchi, India.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4084-5027
Frank-Erik de LeeuwDepartment of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Thomas LimanCenter for Stroke Research Berlin, Berlin, Germany.
Karl Georg HaeuslerDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-6389-5054
Ynte M RuigrokUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.
Peter Ulrich HeuschmannInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2681-3515
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Keum Ji JungNuffield Department of Population Health, University of Oxford, Oxford, UK.
Lisa BastaracheDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Guillaume ParéThrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6795-4760
Scott M DamrauerDepartment of Surgery and Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3357-0862
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Christopher D AndersonCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
John-Anker ZwartDepartment of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-5721-0154
Teemu J NiiranenDepartment of Internal Medicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-7394-7487
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Yung-Po LiawDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6135-2622
Israel Fernández-CadenasStroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9179-0321
Christian T RuffTIMI Study Group, Boston, MA, USA.
Mayowa O OwolabiCenter for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID http://orcid.org/0000-0003-1146-3070
Jennifer E HuffmanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-2491
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Yoichiro KamataniLaboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-0654-387X
Stephanie DebetteBordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France. stephanie.debette@u-bordeaux.fr.
University of Washington · USOslo University Hospital · NOUniversity of Oxford · GBUtrecht University · NLBrigham and Women's Hospital · USUniversity of Ibadan · NGHospital de Sant Pau · ESErasmus MC · NLNorwegian University of Science and Technology · NOUniversitat Autònoma de Barcelona · ESUniversité de Bordeaux · FRBoston University · USBroad Institute · USUniversity of Helsinki · FIUniversity of Tartu · EEHarvard University · USLund University · SEUniversity of Cambridge · GBHelmholtz Zentrum München · DERadboud University Nijmegen · NL
Funding
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MFrom GWAS to PheWAS: Scanning the EMR Phenome for Gene-disease AssociationsR01LM010685 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, LISA · 2011 to 2022
$6.3MGenetic contributors to diabetes and dyslipidemia in African AmericansR01DK084350 · NIDDK · UNIVERSITY OF VIRGINIA · PI SALE, MICHELE M · 2009 to 2010
$4.4MCNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6MDiscovery and Application of Germline and Somatic Mutations for Risk Prediction and Personalized Therapy to Prevent Recurrent Myocardial InfarctionK08HL153950 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARSTON, NICHOLAS · 2020 to 2024
$647kAfrican Neurobiobank for Precision Stroke Medicine - (ELSI) ProjectU01HG010273 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI AKINYEMI, RUFUS OLUSOLA, ARULOGUN, OYEDUNNI SOLA · 2018 to 2022
$512kPrecision Cardio-Metabolic Phenotyping for Genetic Discovery and Risk PredictionIK2CX001780 · VA · PHILADELPHIA VA MEDICAL CENTER · PI DAMRAUER, SCOTT MICHAEL · 2018 to 2023
–BLRD VA I01 BX004821British Heart Foundation CH/12/2/29428British Heart Foundation CH/1996001/9454British Heart Foundation FS/14/55/30806British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946CSRD VA IK2 CX001780Medical Research Council G0300622Medical Research Council MC_EX_G0801669Medical Research Council MC_PC_12027Medical Research Council MC_PC_12028Medical Research Council MC_PC_12029Medical Research Council MC_PC_13049Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_U137686854Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2Medical Research Council MR/S004130/1NHGRI NIH HHS U01 HG010273NHLBI NIH HHS K08 HL153950NHLBI NIH HHS R01 HL105756NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIDDK NIH HHS R01 DK084350NINDS NIH HHS R01 NS114045NINDS NIH HHS U01 NS041588NLM NIH HHS R01 LM010685Wellcome Trust 212946/Z/18/Z
Abstract
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry
Indexed as
Drug DiscoveryGenetic Predisposition to DiseaseIschemic StrokeAfricaAsia, EasternBrain IschemiaEuropeGenome-Wide Association StudyHumansMolecular Targeted TherapyMultifactorial Inheritance
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Read underepoch 390
Registered trials
NCT07553650ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.