ArticleMethods in molecular biology (Clifton, N.J.)2022
Real-Time Monitoring of Circadian Rhythms in the Eye.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex.Investigative ophthalmology & visual science · 2025Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian eye harbors a full circadian system that controls several physiologically relevant functions within this organ. During the last two decades a few laboratories have developed transgenic animal models in which circadian rhythms can be monitored in real time using luciferase activity. The most famous transgenic mouse to record bioluminescence rhythms from different tissues and organs is the PERIOD2::LUCIFERASE (PER2::LUC) mouse developed by the Takahashi laboratory in early 2000. Since then, several studies have used this mouse model to dissect the mammalian circadian system by monitoring the circadian rhythm in the brain, the eye, and in many other peripheral organs and tissues. This chapter describes the methodology to record and analyze bioluminescence rhythms from the retina, retinal pigment epithelium, and cornea of PER2::LUC mice.
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