Evidence map›Paper›PMID 36180605›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2022

Glutathione, polyamine, and lysophosphatidylcholine synthesis pathways are associated with circulating pro-inflammatory cytokines.

Ming Liu, Hongwei Zhang, Zikun Xie, Yiheng Huang, Guang Sun, Dake Qi, Andrew Furey, Edward W Randell, Proton Rahman, Guangju Zhai

Abstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ming LiuDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Hongwei ZhangDiscipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Zikun XieXiangya Hospital, Central South University, Changsha, China.
Yiheng HuangCollege of Pharmacy, University of Manitoba, Winnipeg, Canada.
Guang SunDiscipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Dake QiCollege of Pharmacy, University of Manitoba, Winnipeg, Canada.
Andrew FureyDiscipline of Surgery, Faculty of Medicine, Memorial University of Newfoundland and Office of the Premier, Government of Newfoundland and Labrador, St. John's, Canada.
Edward W RandellDiscipline of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Proton RahmanDiscipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Guangju ZhaiDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada. guangju.zhai@med.mun.ca.
Memorial University of Newfoundland · CAUniversity of Manitoba · CAGovernment of Newfoundland and Labrador · CAXiangya Hospital Central South University · CN

Funding

CIHR FRN#132178CIHR FRN#156116CIHR FRN#175015CIHR MOP192552
6 · The paper itself

Abstract

introductionPro-inflammatory cytokines are responsible for initiating an effective defense against exogenous pathogens, and their regulation has a vital role in maintaining physiological homeostasis. The involvement of pro-inflammatory cytokines in pathological conditions have been explored in great detail, however, studies investigating metabolic pathways associated with these cytokines under normal homeostatic conditions are scarce.

objectivesThe aim of the current study was to identify metabolites and metabolic pathways associated with circulating pro-inflammatory cytokines under homeostatic conditions using a metabolomics approach.

methodsThe study participants (n = 133) were derived from the Newfoundland Osteoarthritis Study (NFOAS) and the Complex Diseases in the Newfoundland population: Environment and Genetics (CODING) study. Plasma concentrations of cytokines including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and macrophage migration inhibitory factor (MIF) were assessed by enzyme-linked immunosorbent assay. Targeted metabolomic profiling on fasting plasma samples was performed using Biocrates MxP® Quant 500 kit which measures a total of 630 metabolites. Associations between natural log-transformed metabolite concentrations and metabolite sums/ratios and cytokine levels were assessed using linear regression with adjustment for age, sex, body mass index (BMI), and osteoarthritis status.

resultsSeven metabolites and 11 metabolite sums/ratios were found to be significantly associated with TNF-α, IL-1β, and MIF (all p ≤ 5.13 × 10

conclusionGSH, polyamine, and lysoPC synthesis pathways were positively associated with circulating TNF-α, IL-1β, and MIF levels under homeostatic conditions.

Indexed as

Macrophage Migration-Inhibitory FactorsOsteoarthritisGlutathioneHumansInterleukin-1betaInterleukin-6LysophosphatidylcholinesMetabolomicsPolyaminesTumor Necrosis Factor-alphaGlutathioneInterleukin-1betaInterleukin-6LysophosphatidylcholinesMacrophage Migration-Inhibitory FactorsPolyaminesTumor Necrosis Factor-alphaGlutathioneLysophosphatidylcholineMetabolomicsPolyaminePro-inflammatory cytokine

Identifiers

PMID36180605
OpenAlexW4298110064

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.