ArticleNature communications2022
Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Chiral discrimination of amino acids in meteorite and desert soil extracts via single-molecule nanogap conductance.Nature communications · 2026Article
- Ru-N coordination hydrogen-bonded organic frameworks with enhanced peroxidase-like activity for colorimetric determination of gastric cancer-related salivary D-amino acids.Mikrochimica acta · 2026Article
- Capillary Integrated SERS System Inspired by Bee-Hive Bionics: Enabling Dynamic Multi-Component Detection of Trace Biomolecules.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Chiral Au@Ag Core-Shell Nanoparticles for Enantioselective SERS Detection of Bio-Relevant Chiral Molecules.ACS nanoscience Au · 2026Article
- Design and Applications of MOF-Based SERS Sensors in Agriculture and Biomedicine.Sensors (Basel, Switzerland) · 2026Review
- Unlocking efficient electrocatalytic removal of trace emerging contaminants via synchronized pollutant enrichment and electron delivery.Nature communications · 2026Article
- Review
- Surface-Enhanced Raman Scattering in Au Nanostructures with Submolecular Gaps for Molecular Size Detection.ACS omega · 2025Article
- Green MGQD@MIP adsorbent for quercetin detection using a spectrophotometric method.Scientific reports · 2025Article
- Advances in surface-enhanced Raman scattering applications for precision agriculture: monitoring plant health and crop quality.RSC advances · 2025Review
- Development of molecularly imprinted polymers for the removal of levofloxacin.BMC chemistry · 2025Article
- A Point-of-Use Assay Based on Surface-Enhanced Raman Spectroscopy for Rapid Determination of Triclosan in Environmental Water and Mouthwash.ACS omega · 2025Article
- MoB QDs/N, F-CDs for ratiometric fluorescence sensing of perfluorooctanoic acid based on fluorine‑fluorine interaction.Mikrochimica acta · 2025Article
- Review
- Chiral Growth of Gold Horns on Polyhedrons for SERS Identification of Enantiomers and Polarized Light-Induced Photothermal Sterilization.Materials (Basel, Switzerland) · 2025Article
- Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Molecularly Imprinted Polymer Advanced Hydrogels as Tools for Gastrointestinal Diagnostics.Gels (Basel, Switzerland) · 2025Review
- A chiral HPLC and pharmacokinetic approach of 1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide.Bioanalysis · 2025Article
- Deep tissue sensing of chiral molecules using polarization-enhanced photoacoustics.Science advances · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral discrimination strategy has not yet been developed because of the inevitable nonspecific binding entity of wrong enantiomers or insufficient intrinsic optical activities of chiral molecules. Here, we propose an "inspector" recognition mechanism (IRM), which is implemented on a chiral imprinted polydopamine (PDA) layer coated on surface-enhanced Raman scattering (SERS) tag layer. The IRM works based on the permeability change of the imprinted PDA after the chiral recognition and scrutiny of the permeability by an inspector molecule. Good enantiomer can specifically recognize and fully fill the chiral imprinted cavities, whereas the wrong cannot. Then a linear shape aminothiol molecule, as an inspector of the recognition status is introduced, which can only percolate through the vacant and nonspecifically occupied cavities, inducing the SERS signal to decrease. Accordingly, chirality information exclusively stems from good enantiomer specific binding, while nonspecific recognition of wrong enantiomer is curbed. The IRM benefits from sensitivity and versatility, enabling absolute discrimination of a wide variety of chiral molecules regardless of size, functional groups, polarities, optical activities, Raman scattering, and the number of chiral centers.
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