Evidence map›Paper›PMID 36180460›Full record

ArticleNature communications2022

FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli.

Zhixin Lyu, Atsushi Yahashiri, Xinxing Yang, Joshua W McCausland, Gabriela M Kaus, Ryan McQuillen, David S Weiss, Jie Xiao

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

  1. A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  10. FtsZ-mediated spatial-temporal control over septal cell wall synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  14. Review
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  20. Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Zhixin LyuDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0001-7668-614X
Atsushi YahashiriDepartment of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Xinxing YangDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Joshua W McCauslandDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Gabriela M KausDepartment of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Ryan McQuillenDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0002-0399-5248
David S WeissDepartment of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. david-weiss@uiowa.edu.
Jie XiaoDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. xiao@jhmi.edu.ORCID 0000-0003-1433-5437
Johns Hopkins University · USUniversity of Iowa · USUniversity of Science and Technology of China · CN

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Spatial Organization and Regulation of Bacterial Cellular ProcessesR35GM136436 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Jie Xiao · 2020 to 2026
$4.8M
Probing the structure, dynamics and function of the E. coli divisomeR01GM086447 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI XIAO, JIE · 2011 to 2019
$3.8M
Peptidoglycan binding protein specificity and bacterial cell divisionR01GM125656 · NIGMS · UNIVERSITY OF IOWA · PI WEISS, DAVID S · 2018 to 2021
$1.3M
NIAID NIH HHS T32 AI007511NIGMS NIH HHS R01 GM086447NIGMS NIH HHS R01 GM125656NIGMS NIH HHS R35 GM136436NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

FtsN plays an essential role in promoting the inward synthesis of septal peptidoglycan (sPG) by the FtsWI complex during bacterial cell division. How it achieves this role is unclear. Here we use single-molecule tracking to investigate FtsN's dynamics during sPG synthesis in E. coli. We show that septal FtsN molecules move processively at ~9 nm s

Indexed as

Escherichia coli ProteinsPeptidoglycanBacterial ProteinsCell DivisionCell WallEscherichia coliMembrane ProteinsBacterial ProteinsEscherichia coli ProteinsFtsN protein, E coliMembrane ProteinsPeptidoglycan

Identifiers

PMID36180460
PMCPMC9525312
OpenAlexW4298140195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.