Evidence map›Paper›PMID 36180328›Full record

ReviewAcademic radiology2023

A Framework for Evaluating the Technical Performance of Multiparameter Quantitative Imaging Biomarkers (mp-QIBs).

Nancy A Obuchowski, Erich Huang, Nandita M deSouza, David Raunig, Jana Delfino, Andrew Buckler, Charles Hatt, Xiaofeng Wang, Chaya Moskowitz, Alexander Guimaraes and 4 more

Abstract readReview
In one paragraph

Review in Academic radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nancy A ObuchowskiQuantitative Health Sciences /JJN3, Cleveland Clinic Foundation, 9500 Euclid Ave. Cleveland, OH 44195. Electronic address: obuchon@ccf.org.
Erich HuangBiometric Research Program, Division of Cancer Treatment and Diagnosis - National Cancer Institute, National Institutes of Health, Huang, Rockville, Maryland.
Nandita M deSouzaDivision of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom; European Imaging Biomarkers Alliance (EIBALL), European Society of Radiology (ESR), Vienna, Austria.
David RaunigData Science Institute, Takeda, Raunig, Hew Hope, PA.
Jana DelfinoCenter for Devices and Radiological Health, US Food and Drug Administration, Delfino, Silver Spring, Maryland.
Andrew BucklerElucid Bioimaging, Inc, Buckler, Boston, MA.
Charles HattUniversity of Michigan, Hatt, Radiology, University of Michigan, Ann Arbor, MI.
Xiaofeng WangQuantitative Health Sciences, Cleveland Clinic Foundation, Wang, Cleveland, OH.
Chaya MoskowitzMemorial Sloan Kettering Cancer Institute, Moskowitz, NYC, NY.
Alexander GuimaraesDepartment of Radiology, Oregon Health and Science University, Guimaraes, Oregon, Portland.
Maryellen GigerDepartment of Radiology, University of Chicago, Giger, Chicago, IL.
Timothy J HallDepartment of Medical Physics, University of Wisconsin, Hall, Madison, WI.
Paul KinahanUniversity of Washington, Kinahan, Seattle, WA.
Gene PennelloDivision of Biostatistics, Center for Devices and Radiological Health, FDA, Pennello, Silver Spring, Maryland.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Multiparameter quantitative imaging incorporates anatomical, functional, and/or behavioral biomarkers to characterize tissue, detect disease, identify phenotypes, define longitudinal change, or predict outcome. Multiple imaging parameters are sometimes considered separately but ideally are evaluated collectively. Often, they are transformed as Likert interpretations, ignoring the correlations of quantitative properties that may result in better reproducibility or outcome prediction. In this paper we present three use cases of multiparameter quantitative imaging: i) multidimensional descriptor, ii) phenotype classification, and iii) risk prediction. A fourth application based on data-driven markers from radiomics is also presented. We describe the technical performance characteristics and their metrics common to all use cases, and provide a structure for the development, estimation, and testing of multiparameter quantitative imaging. This paper serves as an overview for a series of individual articles on the four applications, providing the statistical framework for multiparameter imaging applications in medicine.

Indexed as

Diagnostic ImagingBiomarkersPhenotypeReproducibility of ResultsBiomarkersmultiparametric imagingQIBAquantitative imaging biomarkersradiomics

Identifiers

PMID36180328
PMCPMC9825639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.