Evidence map›Paper›PMID 36180228›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism.

Nathan McChesney, Jeremy L Barth, Jeffrey A Rumschlag, Junying Tan, Adam J Harrington, Kenyaria V Noble, Carolyn M McClaskey, Phillip Elvis, Silvia G Vaena, Martin J Romeo and 3 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Nathan McChesneyDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425.
Jeremy L BarthDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID https://orcid.org/0000-0001-6113-8140
Jeffrey A RumschlagDepartment of Otolaryngology & Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID https://orcid.org/0000-0003-4593-5590
Junying TanDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425.
Adam J HarringtonDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.
Kenyaria V NobleDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425.
Carolyn M McClaskeyDepartment of Otolaryngology & Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID https://orcid.org/0000-0002-0942-6281
Phillip ElvisDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425.
Silvia G VaenaHollings Cancer Institute, Medical University of South Carolina, Charleston, South Carolina 29425.
Martin J RomeoHollings Cancer Institute, Medical University of South Carolina, Charleston, South Carolina 29425.
Kelly C HarrisDepartment of Otolaryngology & Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID https://orcid.org/0000-0001-8486-1219
Christopher W CowanDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID https://orcid.org/0000-0001-5472-3296
Hainan LangDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425 langh@musc.edu.ORCID https://orcid.org/0000-0003-2210-7856
Medical University of South Carolina · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
SPEECH UNDERSTANDING IN REALISTIC ENVIRONMENTSP50DC000422 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 1989 to 2025
$45.3M
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hailong Zhang · 2020 to 2026
$18.7M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
MUSC Minority Student Development ProgramR25GM072643 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE, RINKER, JENNIFER ANNE · 2005 to 2023
$5.8M
SC COBRE for Developmentally Based Cardiovascular DiseasesP30GM103342 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MARKWALD, ROGER R · 2012 to 2016
$5.5M
Interdisciplinary Research Training in Otolaryngology and Communication SciencesT32DC014435 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 2015 to 2024
$2.9M
MUSC Post-Baccalaureate Research Education ProgramR25GM113278 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DELEON-PENNELL, KRISTINE Y, PENROD-MARTIN, RACHEL · 2015 to 2024
$2.7M
Transcriptional Regulation of Synapse Development in Intellectual and Developmental DisordersR01MH111464 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI COWAN, CHRISTOPHER W · 2017 to 2021
$2.2M
Auditory Nerve Degeneration and RepairR01DC012058 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LANG, HAINAN · 2012 to 2016
$1.9M
NCI NIH HHS P30 CA138313NIDCD NIH HHS K18 DC018517NIDCD NIH HHS P50 DC000422NIDCD NIH HHS R01 DC012058NIDCD NIH HHS R56 DC012058NIDCD NIH HHS T32 DC014435NIDDK NIH HHS P30 DK123704NIGMS NIH HHS P20 GM103499NIGMS NIH HHS P20 GM103542NIGMS NIH HHS P20 GM130457NIGMS NIH HHS P30 GM103342NIGMS NIH HHS R25 GM072643NIGMS NIH HHS R25 GM113278NIH HHS S10 OD018113NIH HHS S10 OD028663NIMH NIH HHS R01 MH111464
6 · The paper itself

Abstract

Dysfunction of the peripheral auditory nerve (AN) contributes to dynamic changes throughout the central auditory system, resulting in abnormal auditory processing, including hypersensitivity. Altered sound sensitivity is frequently observed in autism spectrum disorder (ASD), suggesting that AN deficits and changes in auditory information processing may contribute to ASD-associated symptoms, including social communication deficits and hyperacusis. The MEF2C transcription factor is associated with risk for several neurodevelopmental disorders, and mutations or deletions of

Indexed as

Autism Spectrum DisorderAutistic DisorderAnimalsCochlear NerveDisease Models, AnimalFemaleHumansMaleMEF2 Transcription FactorsMiceMEF2 Transcription Factorsauditory nerveautism spectrum disorderglial cellhearingmacrophagesMEF2C

Identifiers

PMID36180228
PMCPMC9617620
OpenAlexW4298109397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.