Evidence map›Paper›PMID 36179671›Full record

ArticleCell2022

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors.

Anders B Dohlman, Jared Klug, Marissa Mesko, Iris H Gao, Steven M Lipkin, Xiling Shen, Iliyan D Iliev

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07783971 (Study on the Microbial Environment of Non-small Cell Lung Cancer Based on Mycogenomics and Its Clinical Relevance), which is not on this map. Cited by 260 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 1 pooled it
29.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07783971 recruitingnot on this mapstarted 2026, after this paper: background citation

Study on the Microbial Environment of Non-small Cell Lung Cancer Based on Mycogenomics and Its Clinical Relevance

TypeobservationalSponsor958th Army Hospital of the Chinese People's Liberation ArmyRan2026 to 2028Enrolled10ConditionsFungal Diseases, Lung Cancer (NSCLC), Microbioata
3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 1 synthesis or guideline pooled it, 369 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anders B DohlmanDepartment of Biomedical Engineering, Center for Genomics and Computational Biology, Duke Microbiome Center, Duke University, Durham, NC 27708, USA. Electronic address: anders.dohlman@duke.edu.
Jared KlugThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Marissa MeskoThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Iris H GaoThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Steven M LipkinJoan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Xiling ShenDepartment of Biomedical Engineering, Center for Genomics and Computational Biology, Duke Microbiome Center, Duke University, Durham, NC 27708, USA; Terasaki Institute, Los Angeles, CA 90024, USA.
Iliyan D IlievThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Electronic address: iliev@med.cornell.edu.
Cornell University · USDuke University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Robust Control of the Stem Cell NicheR35GM122465 · NIGMS · TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION · PI Xiling Shen · 2017 to 2026
$5.6M
Commensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2M
An organotypic model recapitulating colon cancer microenvironment and metastasisU01CA214300 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, EMINA HUI-NA, SHEN, XILING · 2017 to 2021
$3.1M
Regulation and function of mucosal IgA immune responses to mycobiota in the gut.R01AI163007 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2021 to 2025
$2.9M
Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity.R01DK121977 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2020 to 2024
$2.7M
Developing a comprehensive model for peripheral nerve stimulation of gastrointestinal functionR01DK119795 · NIDDK · TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION · PI SHEN, XILING · 2019 to 2022
$1.8M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014236NCI NIH HHS U01 CA214300NIAID NIH HHS R01 AI163007NIDDK NIH HHS R01 DK113136NIDDK NIH HHS R01 DK119795NIDDK NIH HHS R01 DK121977NIGMS NIH HHS R35 GM122465
6 · The paper itself

Abstract

Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the human microbiome, yet little is known about their role in human cancers. Pan-cancer analysis of multiple body sites revealed tumor-associated mycobiomes at up to 1 fungal cell per 10

Indexed as

Lung NeoplasmsMycobiomeBiomarkersCandidaDNA, FungalFungiHumansBiomarkersDNA, FungalBlastomycescancerCandidacolon cancerlung cancerMalasseziamycobiomestomach cancertrans-kingdom interactionstumor-associated fungi

Identifiers

PMID36179671
PMCPMC9564002
OpenAlexW4298008684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.