Evidence map›Paper›PMID 36179665›Full record

ArticleCell2022

The tumor mycobiome: A paradigm shift in cancer pathogenesis.

Xin Li, Deepak Saxena

Abstract readComment
In one paragraph

Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
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  13. Article
  14. Review
  15. Lung microbiota: implications and interactions in chronic pulmonary diseases.Frontiers in cellular and infection microbiology · 2024
    Review
  16. Review
  17. Review
  18. Article
  19. Gut microbiota in colorectal cancer development and therapy.Nature reviews. Clinical oncology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Xin LiDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Urology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Deepak SaxenaDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Surgery, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: ds100@nyu.edu.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Succinate triggers gut dysbiosis and activates SUCNR1 to enhance inflammagingR01AG068857 · NIA · UNIVERSITY OF VIRGINIA · PI LI, XIN, SAXENA, DEEPAK · 2020 to 2024
$2.4M
Regulation of Pancreatic Oncogenesis by the Gut MicrobiomeR01CA206105 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SAXENA, DEEPAK, SIMEONE, DIANE M · 2017 to 2021
$1.9M
Modulation of the gut microbiome to enhance efficacy of immunotherapy in pancreatic adenocarcinomaR41CA250892 · NCI · PERIOMICS CARE, LLC · PI LI, XIN, SAXENA, DEEPAK · 2020 to 2020
$400k
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA206105NCI NIH HHS R41 CA250892NIA NIH HHS R01 AG068857
6 · The paper itself

Abstract

Distinct fungal communities or "mycobiomes" have been found in individual tumor types and are known to contribute to carcinogenesis. Two new studies present a comprehensive picture of the tumor-associated mycobiomes from a variety of human cancers. These studies reveal that fungi, although in low abundance, are ubiquitous across all major human cancers and that specific mycobiome types can be predictive of survival.

Indexed as

MycobiomeNeoplasmsFungiHumans

Identifiers

PMID36179665
PMCPMC10189653

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.