Evidence map›Paper›PMID 36179219›Full record

ArticleG3 (Bethesda, Md.)2022

The future of fungi: threats and opportunities.

Nicola T Case, Judith Berman, David S Blehert, Robert A Cramer, Christina Cuomo, Cameron R Currie, Iuliana V Ene, Matthew C Fisher, Lillian K Fritz-Laylin, Aleeza C Gerstein and 24 more

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. An update on clinically relevant, rare, and emergingClinical microbiology reviews · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Focus on fungi.Cell · 2024
    Article
  16. Review
  17. Machine learning enables identification of an alternative yeast galactose utilization pathway.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 6 countries.

Nicola T CaseDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0000-0001-7692-3424
Judith BermanShmunis School of Biomedical and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0002-8577-0084
David S BlehertU.S. Geological Survey, National Wildlife Health Center, Madison, WI 53711, USA.ORCID 0000-0002-1065-9760
Robert A CramerDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.ORCID 0000-0001-5503-5006
Christina CuomoInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-5778-960X
Cameron R CurrieDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3104-3997
Iuliana V EneDepartment of Mycology, Institut Pasteur, Université de Paris, Paris 75015, France.ORCID 0000-0002-0390-7084
Matthew C FisherMRC Centre for Global Infectious Disease Analysis, Imperial College, London W2 1PG, UK.ORCID 0000-0002-1862-6402
Lillian K Fritz-LaylinDepartment of Biology, University of Massachusetts, Amherst, MA 01003, USA.ORCID 0000-0002-9237-9403
Aleeza C GersteinDepartment of Microbiology and Department of Statistics, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0002-0781-9356
N Louise GlassPlant and Microbial Biology Department, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-4844-2890
Neil A R GowDepartment of Biosciences, University of Exeter, Exeter EX4 4QD, UK.ORCID 0000-0002-2776-5850
Sarah J GurrDepartment of Biosciences, University of Exeter, Exeter EX4 4QD, UK.ORCID 0000-0002-4821-0635
Chris Todd HittingerLaboratory of Genetics, Center for Genomic Science Innovation, J.F. Crow Institute for the Study of Evolution, DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0001-5088-7461
Tobias M HohlInfectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.ORCID 0000-0002-9097-5412
Iliyan D IlievDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-0884-9749
Timothy Y JamesDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1123-5986
Hailing JinDepartment of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California-Riverside, Riverside, CA 92507, USA.ORCID 0000-0001-5778-5193
Bruce S KleinDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3212-1539
James W KronstadMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0003-4240-6976
Jeffrey M LorchU.S. Geological Survey, National Wildlife Health Center, Madison, WI 53711, USA.ORCID 0000-0003-2239-1252
Victoria McGovernBurroughs Wellcome Fund, Durham, NC 13901, USA.ORCID 0000-0001-5153-2910
Aaron P MitchellDepartment of Microbiology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-0868-4000
Julia A SegreMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6860-348X
Rebecca S ShapiroDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-7119-8865
Donald C SheppardMcGill Interdisciplinary Initiative in Infection and Immunology, Departments of Medicine, Microbiology & Immunology, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0001-8877-880X
Anita SilDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94117, USA.ORCID 0000-0002-3987-7534
Jason E StajichDepartment of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California-Riverside, Riverside, CA 92507, USA.ORCID 0000-0002-7591-0020
Eva E StukenbrockMax Planck Fellow Group Environmental Genomics, Max Planck Institute for Evolutionary Biology, Plön 24306, Germany.ORCID 0000-0001-8590-3345
John W TaylorDepartment of Plant and Microbial Biology, University of California-Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-5794-7700
Dawn ThompsonLifeMine Therapeutics, Cambridge, MA 02140, USA.ORCID 0000-0002-1341-4435
Gerard D WrightM.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0002-9129-7131
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Medicine, and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-6369-5995
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0000-0001-5797-0110
University of Wisconsin–Madison · USUnited States Geological Survey · USUniversity of California, Berkeley · USUniversity of California, Riverside · USUniversity of Exeter · GBUniversity of Toronto · CABroad Institute · USBurroughs Wellcome Fund · USChristian-Albrechts-Universität zu Kiel · DECornell University · USDartmouth College · USDuke Medical Center · USImperial College London · GBInstitut Pasteur · FRKettering University · USMcGill University · CAMcMaster University · CANational Institutes of Health · USSage Therapeutics (United States) · USTel Aviv University · IL

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Virulence gene discovery in CoccidioidesU19AI166798 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI George Richard Thompson · 2022 to 2026
$10.5M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal PathogenR01AI127375 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen · 2017 to 2026
$5.3M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR01AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2011 to 2020
$4.9M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
The Genetic Basis of Virulence in Cryptococcus NeoformansR01AI133654 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN, Paul Mitaari Magwene · 2017 to 2026
$4.7M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR37AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2021 to 2026
$4.2M
Evolutionary multispecies transcriptomics to reveal genes that govern fungal spore germination and pathogenesisR01AI146584 · NIAID · YALE UNIVERSITY · PI SIL, ANITA, TOWNSEND, JEFFREY PETER · 2019 to 2023
$3.9M
RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesisR01AI170543 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2022 to 2026
$3.6M
Gene circuits that control morphology in HistoplasmaR37AI066224 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anita Sil · 2020 to 2026
$3.3M
Medical Research Council MR/R015600/1Medical Research Council MR/V033417/1NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI120958NIAID NIH HHS R01 AI127375NIAID NIH HHS R01 AI133654NIAID NIH HHS R01 AI136735NIAID NIH HHS R01 AI139632NIAID NIH HHS R01 AI146584NIAID NIH HHS R21 AI156157NIAID NIH HHS R37 AI039115NIAID NIH HHS R37 AI066224NIAID NIH HHS R37 AI093808NIAID NIH HHS U19 AI166798NIGMS NIH HHS R35 GM143039Wellcome TrustWellcome Trust 219551/Z/19/Z
6 · The paper itself

Abstract

The fungal kingdom represents an extraordinary diversity of organisms with profound impacts across animal, plant, and ecosystem health. Fungi simultaneously support life, by forming beneficial symbioses with plants and producing life-saving medicines, and bring death, by causing devastating diseases in humans, plants, and animals. With climate change, increased antimicrobial resistance, global trade, environmental degradation, and novel viruses altering the impact of fungi on health and disease, developing new approaches is now more crucial than ever to combat the threats posed by fungi and to harness their extraordinary potential for applications in human health, food supply, and environmental remediation. To address this aim, the Canadian Institute for Advanced Research (CIFAR) and the Burroughs Wellcome Fund convened a workshop to unite leading experts on fungal biology from academia and industry to strategize innovative solutions to global challenges and fungal threats. This report provides recommendations to accelerate fungal research and highlights the major research advances and ideas discussed at the meeting pertaining to 5 major topics: (1) Connections between fungi and climate change and ways to avert climate catastrophe; (2) Fungal threats to humans and ways to mitigate them; (3) Fungal threats to agriculture and food security and approaches to ensure a robust global food supply; (4) Fungal threats to animals and approaches to avoid species collapse and extinction; and (5) Opportunities presented by the fungal kingdom, including novel medicines and enzymes.

Indexed as

MycosesAnimalsCanadaEcosystemFungiHumansPlantsecosystem healthfungal pathogensmedical mycologyplant-pathogenic fungisustainabilitywildlife pathogens

Identifiers

PMID36179219
PMCPMC9635647
OpenAlexW4298124603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.