Evidence map›Paper›PMID 36179154›Full record

ArticlePhysical review letters2022

Thermodynamic Control of Activity Patterns in Cytoskeletal Networks.

Alexandra Lamtyugina, Yuqing Qiu, Étienne Fodor, Aaron R Dinner, Suriyanarayanan Vaikuntanathan

Abstract read
In one paragraph

Article in Physical review letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Adaptive nonequilibrium design of actin-based metamaterials: Fundamental and practical limits of control.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Self-organization in amoeboid motility.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandra LamtyuginaDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, USA.
Yuqing QiuDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, USA.
Étienne FodorDepartment of Physics and Materials Science, University of Luxembourg, L-1511 Luxembourg, Luxembourg.
Aaron R DinnerDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, USA.
Suriyanarayanan VaikuntanathanDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, USA.

Funding

Rare-event simulation and analysis for elucidating mechanisms of development and diseaseR35GM136381 · NIGMS · UNIVERSITY OF CHICAGO · PI Aaron Dinner · 2020 to 2026
$2.2M
NIGMS NIH HHS R35 GM136381
6 · The paper itself

Abstract

Biological materials, such as the actin cytoskeleton, exhibit remarkable structural adaptability to various external stimuli by consuming different amounts of energy. In this Letter, we use methods from large deviation theory to identify a thermodynamic control principle for structural transitions in a model cytoskeletal network. Specifically, we demonstrate that biasing the dynamics with respect to the work done by nonequilibrium components effectively renormalizes the interaction strength between such components, which can eventually result in a morphological transition. Our work demonstrates how a thermodynamic quantity can be used to renormalize effective interactions, which in turn can tune structure in a predictable manner, suggesting a thermodynamic principle for the control of cytoskeletal structure and dynamics.

Indexed as

Actin CytoskeletonCytoskeletonActinsThermodynamicsActins

Identifiers

PMID36179154
PMCPMC10014041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.