ArticleScience immunology2022
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- TREM2 plays a critical role in innate immune defense against acute Toxoplasma gondii infection by promoting macrophage antimicrobial activities.PLoS pathogens · 2026Article
- The SATvac model of CD8+ T cell expansion and contraction phases considering memory and effector cell differentiation.PLoS computational biology · 2026Article
- Astrocytic but not Microglial Antigen Presentation Shapes Protective Immunity to Toxoplasma gondii in the Brain.Research square · 2026Article
- Conditional T and NK cell antagonism by a giant and highly conserved orthopoxvirus virulence factor.Research square · 2026Article
- Clinical translation of TLR agonist-modified silicified cancer cell therapy supported by humanized mouse models.Molecular therapy. Oncology · 2025Article
- Article
- Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii.Nature microbiology · 2025Article
- Mgl2Nature communications · 2025Article
- Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils.Nature communications · 2025Article
- Article
- Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity.The Journal of experimental medicine · 2024Article
- Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine.Cell host & microbe · 2024Article
- Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium.The Journal of experimental medicine · 2024Article
- Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death.PLoS pathogens · 2024Article
- Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4bioRxiv : the preprint server for biology · 2023Article
- Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis.Journal for immunotherapy of cancer · 2023Article
- Role of mouse dendritic cell subsets in priming naive CD4 T cells.Current opinion in immunology · 2023Review
- Early T-bet promotes LFA1 upregulation required for CD8+ effector and memory T cell development.The Journal of experimental medicine · 2023Article
- PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis.Frontiers in immunology · 2023Article
- Pericardial and mediastinal fat-associated lymphoid clusters are rapidly activated in an alkane-induced model of systemic lupus erythematosus.Discovery immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
David A ChristianDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7160-9900
Thomas A AdamsDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-9871-9851
Lindsey A ShallbergDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-6573-7327
Anthony T PhanDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2935-6070
Tony E SmithDepartment of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mosana AbrahaDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-7105-4626
Joseph PerryDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2341-8461
Gordon RuthelDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joseph T ClarkDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7764-6000
Gretchen Harms PritchardDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lillian R AronsonDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-4193-2560
Selamawit GossaViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0002-9721-8297
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0001-9568-545X
Ross M KedlDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-9065-7895
Christopher A HunterDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-3092-1428
University of Pennsylvania · USMcMaster University · CANational Institute of Neurological Disorders and Stroke · USUniversity of Colorado Anschutz Medical Campus · US
Funding
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MTranscriptional regulation of vaccine-elicited and infection-elicited CD8+ T cell responsesR01AI066121 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Ross M Kedl · 2007 to 2026
$7.1MMechanisms of combined CD40/TLR adjuvant-elicited cellular immunityU01AI160664 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ADAMS, THOMAS A, HUNTER, CHRISTOPHER A · 2021 to 2025
$3.1MMolecular and cellular basis of Combined Adjuvant-Elicited Cellular ImmunityR01AI126899 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2016 to 2020
$2.5MImpact of early T-bet on CD8 T cell effector responsesR01AI125563 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2016 to 2020
$2.0MUtilizing BATF3-dependent DC to generate vaccine-induced cell mediated immunityR21AI126042 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2016 to 2017
$443kNCI NIH HHS T32 CA009140NIAID NIH HHS R01 AI066121NIAID NIH HHS R01 AI125563NIAID NIH HHS R01 AI126899NIAID NIH HHS R21 AI126042NIAID NIH HHS U01 AI160664
Abstract
In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs) whose role in response to infection is poorly understood. After intraperitoneal immunization with
Indexed as
CD8-Positive T-LymphocytesOmentumDendritic Cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.