SynthesisSports medicine - open2022
Acute and Chronic Effects of Blood Flow Restricted High-Intensity Interval Training: A Systematic Review.
Synthesis in Sports medicine - open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07079280 (Comparison of Acute Micro- and Macrovascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Acute Micro- and Macrovascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults: A Randomized Crossover Trial.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Can blood flow restriction amplify the physiological and performance benefits of interval training in male intermittent-sport athletes? a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Effect of different blood flow restriction training regimens combined with low-intensity training on muscle strength and cardiovascular safety in older adults: a systematic review and network meta-analysis.Frontiers in physiology · 2025Pooled it
- Effects of blood flow restriction combined with high-load training on muscle strength and sports performance in athletes: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Effects of blood flow restriction training on physical fitness among athletes: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Benefits of 6-weeks high-intensity circuit training with or without blood flow restriction on physical fitness in active males: A randomized controlled trial.Journal of exercise science and fitness · 2026Article
- Common and Divergent Physiological Responses to Hypoxia and Heat.Sports medicine (Auckland, N.Z.) · 2026Review
- Effects of High-Intensity Interval Training with Blood Flow Restriction Versus Normobaric Hypoxia on Physiological Parameters in Apparently Healthy Young Men.Sports (Basel, Switzerland) · 2026Article
- Deep learning-integrated multilayer thermal gradient sensing platform for real-time blood flow monitoring.Science advances · 2026Article
- Effects of blood flow restriction combined with interval training on aerobic capacity, anaerobic performance, and sport-specific performance in trained male athletes: a systematic review and meta-analysis.Frontiers in physiology · 2026Review
- Effects of blood flow restriction interval training on aerobic, anaerobic capacity, and muscle strength in healthy adults: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- The Impact of High-Intensity Interval Training on Cardiometabolic, Neurologic, Oncologic, and Pain-Related Outcomes: A Comprehensive Review of Systematic Reviews.Journal of clinical medicine · 2025Review
- Effects of blood flow restriction moderate intensity interval training on aerobic and anaerobic capabilities and lower extremity performance in male college basketball players.BMC sports science, medicine & rehabilitation · 2025Article
- Effect of six weeks of blood flow restriction combined with Tabata training on anaerobic capacity in male badminton players.Frontiers in physiology · 2025Article
- Space exploration and lifestyle medicine: a narrative review of its implications for astronaut health and remote Earth-based environments.Frontiers in physiology · 2025Review
- Resistance Training Causes the Stretch-Induced Force Deficit-A Randomized Cross-Over Study.Sports (Basel, Switzerland) · 2024Article
- Acute Hemodynamic, Metabolic, and Hormonal Responses to a Boxing Exergame with and without Blood Flow Restriction in Non-Athlete Young Individuals.Sports (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe implementation of blood flow restriction (BFR) during exercise is becoming an increasingly useful adjunct method in both athletic and rehabilitative settings. Advantages in pairing BFR with training can be observed in two scenarios: (1) training at lower absolute intensities (e.g. walking) elicits adaptations akin to high-intensity sessions (e.g. running intervals); (2) when performing exercise at moderate to high intensities, higher physiological stimulus may be attained, leading to larger improvements in aerobic, anaerobic, and muscular parameters. The former has been well documented in recent systematic reviews, but consensus on BFR (concomitant or post-exercise) combined with high-intensity interval training (HIIT) protocols is not well established. Therefore, this systematic review evaluates the acute and chronic effects of BFR + HIIT.
methodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to identify relevant studies. A systematic search on 1 February 2022, was conducted on four key databases: ScienceDirect, PubMed, Scopus and SPORTDiscus. Quality of each individual study was assessed using the Physiotherapy Evidence Database (PEDro) scale. Extraction of data from included studies was conducted using an adapted version of the 'Population, Intervention, Comparison, Outcome' (PICO) framework.
resultsA total of 208 articles were identified, 18 of which met inclusion criteria. Of the 18 BFR + HIIT studies (244 subjects), 1 reported both acute and chronic effects, 5 examined acute responses and 12 investigated chronic effects. Acutely, BFR challenges the metabolic processes (vascular and oxygenation responses) during high-intensity repeated sprint exercise-which accelerates central and peripheral neuromuscular fatigue mechanisms resulting in performance impairments. Analysis of the literature exploring the chronic effects of BFR + HIIT suggests that BFR does provide an additive physiological training stimulus to HIIT protocols, especially for measured aerobic, muscular, and, to some extent, anaerobic parameters.
conclusionPresently, it appears that the addition of BFR into HIIT enhances physiological improvements in aerobic, muscular, and, to some extent, anaerobic performance. However due to large variability in permutations of BFR + HIIT methodologies, it is necessary for future research to explore and recommend standardised BFR guidelines for each HIIT exercise type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.