Evidence map›Paper›PMID 36178467›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

The RIPK3 Scaffold Regulates Lung Inflammation During

John D Lyons, Pratyusha Mandal, Shunsuke Otani, Deena B Chihade, Kristen F Easley, David A Swift, Eileen M Burd, Zhe Liang, Michael Koval, Edward S Mocarski and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Necroptosis in bacterial infections.Frontiers in immunology · 2024
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

John D LyonsDepartment of Surgery, Emory Critical Care Center.ORCID 0000-0001-5577-0772
Pratyusha MandalDepartment of Microbiology and Immunology, Emory Vaccine Center.
Shunsuke OtaniDepartment of Surgery, Emory Critical Care Center.
Deena B ChihadeDepartment of Surgery, Emory Critical Care Center.
Kristen F EasleyDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine.
David A SwiftDepartment of Surgery, Emory Critical Care Center.
Eileen M BurdDepartment of Pathology and Laboratory Medicine, and.
Zhe LiangDepartment of Surgery, Emory Critical Care Center.
Michael KovalDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine.
Edward S MocarskiDepartment of Microbiology and Immunology, Emory Vaccine Center.
Craig M CoopersmithDepartment of Surgery, Emory Critical Care Center.
Emory Healthcare · USEmory University · USEmory University Hospital · US

Funding

CYTOMEGALOVIRUS DNA REPLICATION AND RECOMBINATIONR01AI020211 · NIAID · STANFORD UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 1985 to 2021
$5.9M
Mechanisms of Intestinal Integrity in Sepsis and ShockR01GM072808 · NIGMS · WASHINGTON UNIVERSITY · PI COOPERSMITH, CRAIG M · 2005 to 2021
$5.1M
Critical Care Training ProgramT32GM095442 · NIGMS · EMORY UNIVERSITY · PI Craig M Coopersmith · 2011 to 2026
$4.7M
The Impact of Chronic Alcohol Abuse on the Pathophysiology of SepsisR01AA027396 · NIAAA · EMORY UNIVERSITY · PI Craig M Coopersmith, Mandy L Ford · 2019 to 2026
$2.8M
The Impact of Cancer on the Pathophysiology of SepsisR01GM104323 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2013 to 2021
$2.4M
Alcohol and the alveolar epithelial barrierR01AA025854 · NIAAA · EMORY UNIVERSITY · PI KOVAL, MICHAEL H. · 2017 to 2021
$1.9M
3-D Culture ModelsR21AI142507 · NIAID · EMORY UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 2019 to 2020
$429k
RIP-Mediated Signaling in Intestinal Epithelial Cell Death During SepsisF32GM117895 · NIGMS · EMORY UNIVERSITY · PI LYONS, JOHN DANIEL · 2016 to 2016
$28k
NIAAA NIH HHS R01 AA025854NIAAA NIH HHS R01 AA027396NIAID NIH HHS R01 AI020211NIAID NIH HHS R21 AI142507NIGMS NIH HHS F32 GM117895NIGMS NIH HHS R01 GM072808NIGMS NIH HHS R01 GM104323NIGMS NIH HHS T32 GM095442
6 · The paper itself

Abstract

RIPK3 (receptor-interacting protein kinase 3) activity triggers cell death via necroptosis, whereas scaffold function supports protein binding and cytokine production. To determine if RIPK3 kinase or scaffold domains mediate pathology during

Indexed as

PneumoniaPseudomonas aeruginosaAnimalsApoptosisCytokinesHumansInflammationMiceReceptor-Interacting Protein Serine-Threonine KinasesRNA, Small InterferingCytokinesReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humanRipk3 protein, mouseRNA, Small InterferinginflammationnecroptosispneumoniaRIPK1RIPK3

Identifiers

PMID36178467
PMCPMC9986559
OpenAlexW4298088289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.