Evidence map›Paper›PMID 36178369›Full record

ArticleChemical communications (Cambridge, England)2022

Deracemisation and stereoinversion by a nanoconfined bidirectional enzyme cascade: dual control by electrochemistry and selective metal ion activation.

Beichen Cheng, Rachel S Heath, Nicholas J Turner, Fraser A Armstrong, Clare F Megarity

Open access · hybridAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Lessons, connections, hypotheses and predictions from protein film electrochemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  2. Review
  3. Building Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Beichen ChengDepartment of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK. clare.megarity@manchester.ac.uk.ORCID http://orcid.org/0000-0001-5303-9900
Rachel S HeathSchool of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK.ORCID http://orcid.org/0000-0003-1910-8268
Nicholas J TurnerSchool of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK.ORCID http://orcid.org/0000-0002-8708-0781
Fraser A ArmstrongDepartment of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK. clare.megarity@manchester.ac.uk.ORCID http://orcid.org/0000-0001-8041-2491
Clare F MegarityDepartment of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK. clare.megarity@manchester.ac.uk.ORCID http://orcid.org/0000-0002-0331-916X
University of Oxford · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unique ability of the 'electrochemical leaf' (e-Leaf) to drive and control nanoconfined enzyme cascades bidirectionally, while directly monitoring their rate in real-time as electrical current, is exploited to achieve deracemisation and stereoinversion of secondary alcohols using a single electrode in one pot. Two alcohol dehydrogenase enzymes with opposing enantioselectivities, from

Indexed as

Alcohol DehydrogenaseFerredoxinsEdetic AcidElectrochemistryFerredoxin-NADP ReductaseLactobacillusNADPAlcohol DehydrogenaseEdetic AcidFerredoxin-NADP ReductaseFerredoxinsNADP

Identifiers

PMID36178369
PMCPMC9578339
OpenAlexW4298086600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.