ArticleCerebral cortex (New York, N.Y. : 1991)2023
The relevance of heterotopic callosal fibers to interhemispheric connectivity of the mammalian brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- The lipidomic architecture of the mouse brain.Nature · 2026Article
- Fetal Cortical Layers and Midline Histological Alterations in the BTBR Mouse Model of Neurodevelopmental Disorders.Biology · 2026Article
- On the impact of tactile processing on motor cortex: how touch shapes motor behaviour.Brain structure & function · 2026Review
- Mapping corpus callosum architecture: developmental, genetic, and cognitive correlates in youth.bioRxiv : the preprint server for biology · 2026Article
- Microsurgical anatomy of the corpus callosum: a fiber microdissection, tractography and illustrative study.Surgical and radiologic anatomy : SRA · 2026Article
- Voxel-mirrored homotopic connectivity in upper motor neuron-dominant amyotrophic lateral sclerosis is associated with different spread directions.Brain imaging and behavior · 2026Article
- Mapping prefrontal afferents along development.Frontiers in neuroscience · 2026Article
- Qualitative and quantitative analysis of the callosal projections to prefrontal, frontal motor, and parietal areas in the macaque monkey.Brain structure & function · 2025Article
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Comprehensive mapping of the thalamic commissures in the rodent brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Disrupted resting-state interhemispheric functional connectivity in patients with first-episode moyamoya disease.Scientific reports · 2025Article
- Padua Days on Muscle and Mobility Medicine, March 25-29, 2025, Hotel Petrarca, Euganean Thermae, Italy: Program and Abstracts.European journal of translational myology · 2025Article
- Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025Article
- Convergent reductions in interhemispheric functional, structural and callosal connectivity in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Review
- Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity.Nature communications · 2024Article
- Alterations of sleep deprivation on brain function: A coordinate-based resting-state functional magnetic resonance imaging meta-analysis.World journal of psychiatry · 2024Article
- Interhemispheric functional connectivity: an fMRI study in callosotomized patients.Frontiers in human neuroscience · 2024Article
- Brain asymmetry is globally different in males and females: exploring cortical volume, area, thickness, and mean curvature.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The corpus callosum (CC) is the largest white matter structure and the primary pathway for interhemispheric brain communication. Investigating callosal connectivity is crucial to unraveling the brain's anatomical and functional organization in health and disease. Classical anatomical studies have characterized the bulk of callosal axonal fibers as connecting primarily homotopic cortical areas. Whenever detected, heterotopic callosal fibers were ascribed to altered sprouting and pruning mechanisms in neurodevelopmental diseases such as CC dysgenesis (CCD). We hypothesized that these heterotopic connections had been grossly underestimated due to their complex nature and methodological limitations. We used the Allen Mouse Brain Connectivity Atlas and high-resolution diffusion-weighted imaging to identify and quantify homotopic and heterotopic callosal connections in mice, marmosets, and humans. In all 3 species, we show that ~75% of interhemispheric callosal connections are heterotopic and comprise the central core of the CC, whereas the homotopic fibers lay along its periphery. We also demonstrate that heterotopic connections have an essential role in determining the global properties of brain networks. These findings reshape our view of the corpus callosum's role as the primary hub for interhemispheric brain communication, directly impacting multiple neuroscience fields investigating cortical connectivity, neurodevelopment, and neurodevelopmental disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.