Evidence map›Paper›PMID 36177947›Full record

ArticleAnnals of the New York Academy of Sciences2022

Engineering multicellular living systems-a Keystone Symposia report.

Jennifer Cable, Paola Arlotta, Kevin Kit Parker, Alex J Hughes, Katharine Goodwin, Christine L Mummery, Roger D Kamm, Sandra J Engle, Danilo A Tagle, Sylvia F Boj and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Jennifer CablePhD Science Writer, New York, New York, USA.
Paola ArlottaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Kevin Kit ParkerWyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
Alex J HughesDepartment of Bioengineering, School of Engineering and Applied Science and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Katharine GoodwinLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Christine L MummeryDepartment of Anatomy and Embryology and LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, the Netherlands.
Roger D KammDepartment of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Sandra J EngleTranslational Biology, Biogen, Cambridge, Massachusetts, USA.
Danilo A TagleNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Sylvia F BojHubrecht Organoid Technology (HUB), Utrecht, the Netherlands.
Alice E StantonDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Yoshihiro MorishitaLaboratory for Developmental Morphogeometry, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Melissa L KempThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Dennis A NorfleetThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Elebeoba E MayDepartment of Biomedical Engineering and HEALTH Research Institute, University of Houston, Houston, Texas, USA.
Aric LuWyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
Rashid BashirBeckman Institute for Advanced Science and Technology, Urbana, Illinois, USA.
Adam W FeinbergDepartment of Biomedical Engineering and Department of Materials Science & Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Sarah M HullDepartment of Chemical Engineering, Stanford University, Stanford, California, USA.
Anjelica L GonzalezDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Michael R BlatchleyBioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado, USA.
Núria Montserrat PulidoInstitute for Bioengineering of Catalonia, Catalonia, Spain.
Ryuji MorizaneNephrology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
Todd C McDevittThe Gladstone Institutes and Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
Deepak MishraDepartment of Biological Engineering, Synthetic Biology Center, Cambridge, Massachusetts, USA.
Adriana Mulero-RusseParker H. Petit Institute for Bioengineering and Bioscience and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.

Funding

Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUH3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2019 to 2021
$3.3M
Recreating Kidney Organogenesis in vitro with Human Pluripotent Stem CellsDP2DK133821 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MORIZANE, RYUJI · 2019 to 2019
$2.5M
Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editingU01DK127587 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, JENNIFER A., MORIZANE, RYUJI · 2020 to 2022
$2.1M
NCATS NIH HHS UH3 TR002155NIDDK NIH HHS DP2 DK133821NIDDK NIH HHS U01 DK127587
6 · The paper itself

Abstract

The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3-6, 2022, experts in the field met at the Keystone symposium "Engineering Multicellular Living Systems" to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium "Organoids as Tools for Fundamental Discovery and Translation".

Indexed as

EngineeringOrganoidsHumansTissue Engineeringcomputationalengineered livingengineered organsmulticellularsystems

Identifiers

PMID36177947
PMCPMC9771928

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.