Evidence map›Paper›PMID 36177884›Full record

ArticleInfection control and hospital epidemiology2023

Molecular concordance of methicillin-resistant

Timileyin Y Adediran, Stephanie Hitchcock, J Kristie Johnson, O Colin Stine, Surbhi Leekha, Kerri A Thom, Yuanyuan Liang, David A Rasko, Anthony D Harris

Open access · hybridAbstract read
In one paragraph

Article in Infection control and hospital epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Timileyin Y AdediranDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7872-4338
Stephanie HitchcockDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.
J Kristie JohnsonDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland.
O Colin StineDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3974-3752
Surbhi LeekhaDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0002-4565-6439
Kerri A ThomDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Yuanyuan LiangDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0001-7409-3391
David A RaskoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7337-7154
Anthony D HarrisDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
University of Maryland, Baltimore · US

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, OWEN R · 2014 to 2023
$36.5M
EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
Epidemiology of CRE and MRSA transmission: patient and organism factorsR01AI121146 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRIS, ANTHONY D · 2016 to 2019
$2.5M
NIAID NIH HHS R01 AI121146NIAID NIH HHS U19 AI110820NIGMS NIH HHS R25 GM055036
6 · The paper itself

Abstract

backgroundMethicillin-resistant

methodsFrom a multisite cohort of 388 independent patient MRSA isolates and their corresponding HCP gown and glove isolates, we selected 91 isolates pairs using a probability to proportion size (PPS) sampling method. To determine whether the patient and HCP gown or gloves isolates were genetically similar, we used 5 comparative genomic typing methods: phylogenetic analysis,

resultsWe identified that 56 (61.5%) of isolate pairs were genetically similar at least by 4 of the methods. Comparably, the

conclusionsMany of the patient MRSA isolates were genetically similar to those on the HCP gown or gloves following a patient care activity. This finding indicates that the patient is often the primary source of the MRSA isolates transmitted to the HCP, which can potentially be spread to other patients or hospital settings through HCP vectors. These results have important implications because they provide additional evidence for hospitals considering ending the use of contact precautions (gloves and gowns) for MRSA patients.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsHealth PersonnelHumansMultilocus Sequence TypingPhylogeny

Identifiers

PMID36177884
PMCPMC10060437
OpenAlexW4298086422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.