Evidence map›Paper›PMID 36177665›Full record

ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2023

Circulating endothelial precursor cells are associated with a healed diabetic foot ulcer evaluated in a prospective cohort study.

David J Margolis, Nandita Mitra, Ole Hoffstad, D Scot Malay, Ziad K Mirza, John C Lantis, Hadar A Lev-Tov, Robert S Kirsner, Deepa Ruhela, Veena M Bhopale and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

David J MargolisDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0506-8085
Nandita MitraDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7714-3910
Ole HoffstadDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0261-903X
D Scot MalayDepartment of Surgery, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2400-5629
Ziad K MirzaMVS Woundcare and Hyperbarics, Towson, Maryland, USA.ORCID 0000-0002-7270-1952
John C LantisDepartment of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York City, USA.ORCID 0000-0002-3615-6512
Hadar A Lev-TovDepartment of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida, USA.ORCID 0000-0001-6223-7001
Robert S KirsnerDepartment of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida, USA.ORCID 0000-0002-6824-9844
Deepa RuhelaDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8308-7727
Veena M BhopaleDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5057-1739
Stephan R ThomDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-3533-6124
University of Maryland, Baltimore · USUniversity of Pennsylvania · USUniversity of Miami · USIcahn School of Medicine at Mount Sinai · USNephroCare · ESPenn Presbyterian Medical Center · US

Funding

Inflammatory changes and glymphatic dysfunction in carbon monoxide neuropathologyR01NS122855 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI STEPHEN RAYMOND THOM · 2022 to 2026
$2.9M
NOS1AP and Capon Associated Impaired Healing in Those with Diabetic Foot UlcersR01DK116199 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MARGOLIS, DAVID, THOM, STEPHEN RAYMOND · 2018 to 2021
$2.3M
NIDDK NIH HHS R01 DK116199NINDS NIH HHS R01 NS122855
6 · The paper itself

Abstract

The goal of this multicentre study was to evaluate whether circulating endothelial precursor cells and microparticles can predict diabetic foot ulcer healing by the 16th week of care. We enrolled 207 subjects, and 40.0% (28.4, 41.5) healed by the 16th week of care. Using flow cytometry analysis, several circulating endothelial precursor cells measured at the first week of care were associated with healing after adjustment for wound area and wound duration. For example, CD34

Indexed as

Diabetes MellitusDiabetic FootHumansPrognosisProspective StudiesWound Healingbiomarkerdiabetic foot ulcerendothelial precursor cells

Identifiers

PMID36177665
PMCPMC10319405
OpenAlexW4298088827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.