ArticleHuman brain mapping2023
White matter microstructure shows sex differences in late childhood: Evidence from 6797 children.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Associations between psychological resilience and metrics of white matter microstructure in pediatric concussion.Human brain mapping · 2023Trial
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- Intergenerational neuroimaging's present and future: Considering sex as a biological variable to enhance knowledge of brain development through parent-offspring similarity.Developmental cognitive neuroscience · 2025Review
- The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, Biomarker Imaging, and Precision Therapeutic Frontiers.International journal of molecular sciences · 2025Review
- Multivariate Links Between the Developmental Timing of Adversity Exposure and White Matter Tract Connectivity in Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Linking Psychotic-Like Experiences and Brain White Matter Microstructure in Young Women.Brain and behavior · 2025Article
- Microstructural Characterization of Short Association Fibers Related to Long-Range White Matter Tracts in Normative Development.Human brain mapping · 2025Article
- Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI.Scientific data · 2025Article
- Sleep moderates how prenatal and childhood pollutant exposure impacts white matter microstructural integrity in adolescence.Npj biological timing and sleep · 2025Article
- More similarity than difference: Comparison of within- and between-sex variance in early adolescent brain structure.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- More similarity than difference: comparison of within- and between-sex variance in early adolescent brain structure.Research square · 2024Article
- Sex-related variability of white matter tracts in the whole HCP cohort.Brain structure & function · 2024Article
- Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences.Communications medicine · 2024Article
- Sex and mental health are related to subcortical brain microstructure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sex Differences in White Matter Diffusivity in Children with Developmental Dyslexia.Children (Basel, Switzerland) · 2024Article
- Sex Differences in the Brain's White Matter Microstructure during Development assessed using Advanced Diffusion MRI Models.bioRxiv : the preprint server for biology · 2024Article
- Sex, gender diversity, and brain structure in early adolescence.Human brain mapping · 2024Article
- Diffusion MRI harmonization via personalized template mapping.Human brain mapping · 2024Article
- Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease.Magnetic resonance in medicine · 2024Article
- Associations Between Socioeconomic Status, Obesity, Cognition, and White Matter Microstructure in Children.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Sex differences in white matter microstructure have been robustly demonstrated in the adult brain using both conventional and advanced diffusion-weighted magnetic resonance imaging approaches. However, sex differences in white matter microstructure prior to adulthood remain poorly understood; previous developmental work focused on conventional microstructure metrics and yielded mixed results. Here, we rigorously characterized sex differences in white matter microstructure among over 6000 children from the Adolescent Brain Cognitive Development study who were between 9 and 10 years old. Microstructure was quantified using both the conventional model-diffusion tensor imaging (DTI)-and an advanced model, restriction spectrum imaging (RSI). DTI metrics included fractional anisotropy (FA) and mean, axial, and radial diffusivity (MD, AD, RD). RSI metrics included normalized isotropic, directional, and total intracellular diffusion (N0, ND, NT). We found significant and replicable sex differences in DTI or RSI microstructure metrics in every white matter region examined across the brain. Sex differences in FA were regionally specific. Across white matter regions, boys exhibited greater MD, AD, and RD than girls, on average. Girls displayed increased N0, ND, and NT compared to boys, on average, suggesting greater cell and neurite density in girls. Together, these robust and replicable findings provide an important foundation for understanding sex differences in health and disease.
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