Evidence map›Paper›PMID 36177446›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2022

Sleep duration and biomarkers of inflammation in African American and white participants with a parental history of Alzheimer's disease.

Victoria M Pak, Sudeshna Paul, Dominika Swieboda, Monique S Balthazar, Whitney Wharton

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Sleep and daily pain intensity among Black and White dementia caregivers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Victoria M PakSchool of Nursing Emory University Atlanta Georgia USA.
Sudeshna PaulSchool of Nursing Emory University Atlanta Georgia USA.
Dominika SwiebodaSchool of Nursing Emory University Atlanta Georgia USA.
Monique S BalthazarSchool of Nursing Emory University Atlanta Georgia USA.
Whitney WhartonSchool of Nursing Emory University Atlanta Georgia USA.
Emory University · US

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WALKER, LARY C · 2005 to 2019
$25.7M
Inflammation and Renin-Angiotensin System Dysfunction as risk factors for ADRF1AG051514 · NIA · EMORY UNIVERSITY · PI NORRIS, CHRISTOPHER MARK, WALKER, LARY C · 2015 to 2017
$3.6M
Preclinical Alzheimer's Disease Biomarkers: Effects of Midlife Vascular FactorsK01AG042498 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI WHARTON, WHITNEY LEE · 2013 to 2017
$617k
NIA NIH HHS K01 AG042498NIA NIH HHS P50 AG025688NIA NIH HHS RF1 AG051514NIMHD NIH HHS L32 MD016549
6 · The paper itself

Abstract

Introduction: African Americans (AA)s have worse inflammation, worse sleep, and a greater incidence of Alzheimer's disease (AD) compared to whites; however, no studies have examined associations between biomarkers, sleep, and cognition, and differences by race. Methods: Seventy-six cognitively normal, middle aged (45-65 years) adults with a parental history of AD were included in this study. Associations between biomarkers (tumor necrosis factor-α [TNF-α], interleukin-10 [IL-10], intercellular adhesion molecule-1 [ICAM-1],, and C-reactive protein [CRP]) and self-reported sleep or cognition measures, were assessed. Results: Average sleep duration was significantly lower for AA versus whites (average[SD]) in hours: 6.02(1.18) versus 7.23(0.91), Discussion: Longer sleep duration is positively associated with plasma IL-10 levels irrespective of race. Sleep quality was positively associated with CSF ICAM-1 only in African Americans.

Indexed as

Alzheimer's diseasebiomarkercerebrospinal fluidcognitioninflammationparental historyracesleep

Identifiers

PMID36177446
PMCPMC9473642
OpenAlexW4295789130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.