ArticleBrain, behavior, & immunity - health2022
Examining the relationships between adverse childhood experiences (ACEs), cortisol, and inflammation among young adults.
Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Exploring Patient Preferences for Adverse Childhood Experiences Education in the Primary Care Setting: A Focus Group Study.The Permanente journal · 2026Article
- Unifying the hallmarks of major depression through neuroimmune-metabolic-oxidative (NIMETOX) dysregulation: a mechanistic systems framework.Cellular & molecular immunology · 2026Review
- Adverse Childhood Experiences and Growth Outcomes in Childhood: A Longitudinal EHR-Based Study.medRxiv : the preprint server for health sciences · 2026Article
- Emerging Perspectives on Adverse Childhood Experiences and Brain Cancer Immunotherapy.Cancers · 2026Article
- The Impact of Adverse Childhood Experiences on Nicotine Withdrawal Symptoms.International journal of mental health and addiction · 2026Article
- Adverse childhood experiences and the risk of endometriosis-a nationwide cohort study.Human reproduction (Oxford, England) · 2025Article
- Adult Mental Health Associated with Adverse and Positive Childhood Experiences Among 1Journal of general internal medicine · 2025Article
- Associations Between Adverse Childhood Experiences and Prenatal Mental Health in the French EDEN Cohort: Cumulative, Person-Centered, and Dimensional Approaches.Depression and anxiety · 2025Article
- Associations of adverse childhood experiences with blood pressure among early adolescents in the United States.American journal of preventive cardiology · 2024Article
- Inflammation and olfactory loss are associated with at least 139 medical conditions.Frontiers in molecular neuroscience · 2024Article
- Econeurobiology and brain development in children: key factors affecting development, behavioral outcomes, and school interventions.Frontiers in public health · 2024Review
- A role for adverse childhood experiences and depression in preeclampsia.Journal of clinical and translational science · 2024Article
- The adipose tissue keeps the score: priming of the adrenal-adipose tissue axis by early life stress predisposes women to obesity and cardiometabolic risk.Frontiers in endocrinology · 2024Review
- Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations.Brain, behavior, & immunity - health · 2023Article
- The Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study.Epigenetics insights · 2022Article
- From Dysregulation to Coherence: Exploring the HeartMathGlobal advances in integrative medicine and healthArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Adverse childhood experiences (ACEs) are associated with dysregulation of inflammation and cortisol. The objectives of this study were to use principal component analysis to explore the inflammatory biomarker data to create inflammation composite variables; to examine the relationship between these composite measures of inflammation with ACEs and cortisol; and to assess whether these relationships were moderated by sex. The analysis included 232 young adults from the Niagara Longitudinal Heart Study (NLHS). After adjusting for covariates, higher exposure to ACEs significantly predicted higher low-grade inflammation. These results further support the use of multiple biomarkers to understand the complex relationships among ACEs, cortisol, and inflammation, which should be further examined in longitudinal studies to study biomarker trajectories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.