Evidence map›Paper›PMID 36177269›Full record

ArticleBJR case reports2022

A tumor association to be aware: endometrial cancer and colon cancer in relation to Lynch syndrome.

Behyamet Onka, Daoud Ali Mohamed, Romeo Thierry Tessi Yehouenou, Boris Adeyemi, Wend-Yam Mohammed Traore, Mbina Mbougou Kevin Arthur, Hounayda Jerguigue, Rachida Latib, Youssef Omor

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PubMed Full text at PMC Publisher
In one paragraph

Article in BJR case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Behyamet OnkaDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.ORCID https://orcid.org/0000-0002-6204-7977
Daoud Ali MohamedDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Romeo Thierry Tessi YehouenouDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Boris AdeyemiDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Wend-Yam Mohammed TraoreDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Mbina Mbougou Kevin ArthurDepartment of emergency, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Hounayda JerguigueDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Rachida LatibDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Youssef OmorDepartment of Radiology, National Institute of Oncology, University Hospital Center IBN SINA, Mohamed V University, Faculty of Medicine, Rabat, Morocco.
Mohammed V University · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

lynch syndrome (LS) is an autosomal dominant genetic disorder with incomplete penetration caused by a germline mutation in one of the genes of the deoxyribonucleic acid (DNA) mismatch repair system (MMR) namely: mutL homolog 1 (MLH1), mutS homolog 2 (MSH2), mutS homolog 6 (MHS6), post-meiotic segregation increased 1 homolog 2 (PMS2) or the EpCAM (Epithelial CellAdhesionMolecule) gene, which causes the inactivation of MSH2. Patients with this syndrome have a high relative risk of developing cancers at a young age, led by colorectal cancer (CRC) and endometrial cancer in females. The diagnosis is suspected when the patient's personal and family history meets the Amsterdam or Bethesda criteria. It is guided by immunohistochemistry (IHC) and/or molecular biology that show loss of expression of one or more proteins of the MMR system and microsatellite instability on tumor DNA. In case of positive IHC and/or molecular biology, the patient should be referred to an oncogenetic consultation for a definitive diagnosis. We present the case of a 49-year-old patient who presented an anamic syndrome in metrorrhagia. After a clinical, imaging, biological and anatomopathological examination, the diagnosis of LS was made.

Identifiers

PMID36177269
PMCPMC9499431
OpenAlexW4205330162

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