Evidence map›Paper›PMID 36177108›Full record

ArticleFood chemistry. Molecular sciences2022

Functional properties of bioactive compounds from

Débora Gonçalves Bortolini, Giselle Maria Maciel, Isabela de Andrade Arruda Fernandes, Alessandra Cristina Pedro, Fernanda Thaís Vieira Rubio, Ivanise Guiherme Branco, Charles Windson Isidoro Haminiuk

Open access · goldAbstract read
In one paragraph

Article in Food chemistry. Molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 184 citations in OpenAlex.

  1. Pooled it
  2. Pharmacological insights intoFrontiers in pharmacology · 2025
    Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. In-feedFrontiers in physiology · 2026
    Article
  13. Frontiers in microbiology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Ultrasound-Assisted Extraction of Bioactives fromFoods (Basel, Switzerland) · 2025
    Article
  20. House Cricket (Nutrients · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Débora Gonçalves BortoliniUniversidade Federal do Paraná (UFPR), Programa de Pós-Graduação em Engenharia de Alimentos (PPGEAL), Curitiba, Paraná CEP (81531-980), Brazil.
Giselle Maria MacielUniversidade Tecnológica Federal do Paraná (UTFPR), Departamento Acadêmico de Química e Biologia (DAQBi), Laboratório de Biotecnologia, Curitiba, Paraná CEP (81280-340), Brazil.
Isabela de Andrade Arruda FernandesUniversidade Federal do Paraná (UFPR), Programa de Pós-Graduação em Engenharia de Alimentos (PPGEAL), Curitiba, Paraná CEP (81531-980), Brazil.
Alessandra Cristina PedroUniversidade Federal do Paraná (UFPR), Programa de Pós-Graduação em Engenharia de Alimentos (PPGEAL), Curitiba, Paraná CEP (81531-980), Brazil.
Fernanda Thaís Vieira RubioUniversidade de São Paulo, Escola Politécnica, Department of Chemical Engineering, Main Campus, São Paulo, São Paulo 05508-080, Brazil.
Ivanise Guiherme BrancoUniversidade Estadual Paulista (UNESP), Departamento de Ciências Biológicas, Assis, São Paulo, São Paulo 19806-900, Brazil.
Charles Windson Isidoro HaminiukUniversidade Tecnológica Federal do Paraná (UTFPR), Departamento Acadêmico de Química e Biologia (DAQBi), Laboratório de Biotecnologia, Curitiba, Paraná CEP (81280-340), Brazil.
Universidade Federal do Paraná · BRUniversidade Tecnológica Federal do Paraná · BRUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional foods show non-toxic bioactive compounds that offer health benefits beyond their nutritional value and beneficially modulate one or more target functions in the body. In recent decades, there has been an increase in the trend toward consuming foods rich in bioactive compounds, less industrialized, and with functional properties. Spirulina, a cyanobacterium considered blue microalgae, widely found in South America, stands out for its rich composition of bioactive compounds, as well as unsaturated fatty acids and essential amino acids, which contribute to basic human nutrition and can be used as a protein source for diets free from animal products. In addition, they have colored compounds, such as chlorophylls, carotenoids, phycocyanins, and phenolic compounds which can be used as corants and natural antioxidants. In this context, this review article presents the main biological activities of spirulina as an anticancer, neuroprotective, probiotic, anti-inflammatory, and immune system stimulating effect. Furthermore, an overview of the composition of spirulina, its potential for different applications in functional foods, and its emerging technologies are covered in this review.

Indexed as

AminoacidsCarotenoidsMicroalgaePhenolic compoundsPhycocyaninUnsaturated fatty acids

Identifiers

PMID36177108
PMCPMC9513730
OpenAlexW4296260796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.