Evidence map›Paper›PMID 36177049›Full record

ArticleFrontiers in immunology2022

Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment.

Li Yu, Lingwei Wang, Guang Hu, Laibin Ren, Chen Qiu, Shun Li, Xiaohui Zhou, Shanze Chen, Rongchang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Li YuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Lingwei WangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Guang HuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Laibin RenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Chen QiuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Shun LiDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiaohui ZhouDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shanze ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Rongchang ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Southern University of Science and Technology · CNShanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular energy metabolism plays a crucial role in the regulation of macrophage polarization and in the execution of immune functions. A recent study showed that Slc6a8-mediated creatine uptake from exogenous supplementation modulates macrophage polarization, yet little is known about the role of the

Indexed as

AsthmaCreatineAmidinotransferasesAnimalsInterleukin-4MacrophagesMiceMice, KnockoutNitric OxideAmidinotransferasesCreatineglycine amidinotransferaseInterleukin-4Nitric Oxideasthmacreatineglycine amidinotransferase (GATM)macrophagepolarization

Identifiers

PMID36177049
PMCPMC9513582
OpenAlexW4297888401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.