Evidence map›Paper›PMID 36176908›Full record

ArticleActa pharmaceutica Sinica. B2022

Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression.

Rui Cui, Luo Wang, Dongyun Zhang, Kun Zhang, Jianping Dou, Linan Dong, Yixuan Zhang, Jiapeng Wu, Longfei Tan, Jie Yu and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Rui CuiDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Luo WangDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Dongyun ZhangDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Kun ZhangLaboratory of Controllable Preparation and App Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Jianping DouDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Linan DongDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Yixuan ZhangDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Jiapeng WuDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Longfei TanLaboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Jie YuDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Ping LiangDepartment of Interventional Ultrasound, PLA General Hospital, Beijing 100853, China.
Chinese PLA General Hospital · CNChinese Academy of Sciences · CNSun Yat-sen University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite being a common therapy for hepatocellular carcinoma (HCC), insufficient thermal ablation can leave behind tumor residues that can cause recurrence. This is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic role. To address this problem, we designed d-mannose-chelated iron oxide nanoparticles (man-IONPs) to polarize M2-like macrophages into the antitumor M1 phenotype.

Indexed as

Hepatocellular carcinomaIron oxide nanoparticleMacrophage polarizationMicrowave ablationTargeted therapy

Identifiers

PMID36176908
PMCPMC9513490
OpenAlexW4281700525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.