Evidence map›Paper›PMID 36176821›Full record

ArticleCureus2022

Hashimoto's Thyroiditis Encephalopathy Induced by COVID-19 Infection.

Misbahuddin Khaja, Zaheer A Qureshi, Kazi Samsuddoha, Vikram Itare, Petr Stastka, Jaydeep Mahasamudram, Faryal Altaf, Arundhati Dileep

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Misbahuddin KhajaInternal Medicine/Pulmonary Critical Care, Icahn School of Medicine at Mount Sinai/BronxCare Health System, New York City, USA.
Zaheer A QureshiInternal Medicine, St. Vincent Medical Center, Bridgeport, USA.
Kazi SamsuddohaInternal Medicine, BronxCare Health System, New York City, USA.
Vikram ItareInternal Medicine, BronxCare Health System, New York City, USA.
Petr StastkaInternal Medicine, American University of the Caribbean School of Medicine, Cupecoy, SXM.
Jaydeep MahasamudramInternal Medicine, BronxCare Health System, New York City, USA.
Faryal AltafInternal Medicine, BronxCare Health System, New York City, USA.
Arundhati DileepPulmonary Medicine, BronxCare Health System, New York City, USA.
MemorialCare Health System · USAmerican University of the Caribbean School of Medicine · SXIcahn School of Medicine at Mount Sinai · USSt. Vincent's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various factors can lead to thyroiditis, including any acute inflammatory process, especially viral illness. While coronavirus disease 2019 (COVID-19) has been linked to disorders of various systems, there is a lack of literature showing an association of coronavirus with the cause of Hashimoto's thyroiditis. Several possible mechanisms for this outcome have been proposed; chief among them is molecular mimicry. Here, we are reporting a case of Hashimoto's thyroiditis incited by COVID-19 in a 34-year-old obese female who presented with anxiety, behavioral changes, and repeated head movements. The patient had an elevated thyroid stimulating hormone (TSH) level, a low thyroxine (T4) level, and a positive anti-microsomal antibody screen. The patient also tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. Ultrasound of the patient's neck showed an enlarged heterogeneous thyroid gland. Thyroid replacement therapy with intravenous levothyroxine was started with the subsequent oral transition. Concurrently, she received antibiotics, steroids, and low-molecular-weight heparin for COVID-19. The patient exhibited significant improvement in her mental status, with an eventual return to baseline. The results of the thyroid panel obtained at the outpatient follow-up were normal. Although there is a paucity of data to show COVID-19 as a cause of this painless thyroiditis, this case demonstrates such causality between these two.

Indexed as

autoimmunecoronaviruscovid 19covid-19 outbreakhashimotohashimoto’s encephalopathythyroidthyroiditisviral disease

Identifiers

PMID36176821
PMCPMC9509523
OpenAlexW4293206595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.