Evidence map›Paper›PMID 36176648›Full record

ArticleKidney3602022

KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.

Karl A Nath, Raman Deep Singh, Anthony J Croatt, Allan W Ackerman, Joseph P Grande, Khasayarsha Khazaie, Y Eugene Chen, Jifeng Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney360, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Karl A NathDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-9869-5506
Raman Deep SinghDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-1441-2722
Anthony J CroattDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Allan W AckermanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Joseph P GrandeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5674-1682
Khasayarsha KhazaieDepartment of Immunology, Mayo Clinic, Phoenix, Arizona.
Y Eugene ChenDepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, Michigan.ORCID 0000-0003-2357-7825
Jifeng ZhangDepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, Michigan.ORCID 0000-0001-5161-4705
Mayo Clinic · USUniversity of Michigan · USMayo Clinic Hospital · US

Funding

KLF14 and Cardiovascular DiseaseR01HL134569 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2017 to 2024
$5.3M
NHLBI NIH HHS R01 HL134569
6 · The paper itself

Abstract

Discovering new nephroprotectants may provide therapeutic strategies in AKI.This study provides the first evidence that KLF11, a member of the Krüppel-like factor (KLF) family of proteins, protects against AKI.In the absence of KLF11, exaggerated induction of endothelin-1 and IL-6 occurs after ischemic renal injury and may contribute to worse AKI.

Indexed as

Acute Kidney InjuryApoptosis Regulatory ProteinsReperfusion InjuryRepressor ProteinsEndothelin-1HumansInterleukin-6KidneyKruppel-Like Transcription FactorsProtective AgentsApoptosis Regulatory ProteinsEndothelin-1Interleukin-6KLF11 protein, humanKruppel-Like Transcription FactorsProtective AgentsRepressor Proteinsacute kidney injuryacute kidney injury and ICU nephrologybasic scienceendothelin-1heme oxygenase-1IL-6KLF11protectantreperfusion injury

Identifiers

PMID36176648
PMCPMC9416845
OpenAlexW4229027101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.