Evidence map›Paper›PMID 36176611›Full record

ReviewBioengineering & translational medicine2022

Advanced strategies to thwart foreign body response to implantable devices.

Simone Capuani, Gulsah Malgir, Corrine Ying Xuan Chua, Alessandro Grattoni

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 148 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Localized inflammasome inhibition mitigates foreign body response to subcutaneous long-acting antiretroviral therapy for HIV.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Simone CapuaniDepartment of Nanomedicine Houston Methodist Research Institute Houston Texas USA.ORCID https://orcid.org/0000-0003-0050-7613
Gulsah MalgirDepartment of Nanomedicine Houston Methodist Research Institute Houston Texas USA.
Corrine Ying Xuan ChuaDepartment of Nanomedicine Houston Methodist Research Institute Houston Texas USA.ORCID https://orcid.org/0000-0002-5724-8715
Alessandro GrattoniDepartment of Nanomedicine Houston Methodist Research Institute Houston Texas USA.ORCID https://orcid.org/0000-0001-7888-422X
Houston Methodist · US

Funding

A novel nanochannel system for sustained delivery of Tenofovir Alafenamide Fumarate and Emtricitabine for HIV pre-exposure prophylaxisR01AI120749 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI GRATTONI, ALESSANDRO · 2016 to 2020
$3.9M
A nanofluidic platform for tunable drug deliveryR01GM127558 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI GRATTONI, ALESSANDRO, LIU, XUEWU · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI120749NIGMS NIH HHS R01 GM127558
6 · The paper itself

Abstract

Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long-term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and long lasting IMDs. This review gives an overview of FBR as well as anti-FBR strategies. Furthermore, we highlight recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

Indexed as

biomimeticforeign body responseimmune modulationimplantable devices

Identifiers

PMID36176611
PMCPMC9472022
OpenAlexW4212927278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.