ArticleBioengineering & translational medicine2022
A bioprinted complex tissue model for myotendinous junction with biochemical and biophysical cues.
Article in Bioengineering & translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Programmable continuous gradient bioprinting for engineering spatially heterogeneous microenvironments.Materials today. Bio · 2026Article
- Aligned multicompartment collagen scaffolds support stratified myoblast and fibroblast behavior for musculotendinous tissue engineering.bioRxiv : the preprint server for biology · 2026Article
- Optimizing strategies in tendon tissue engineering through effective scaffold design: overview of recent advancements.Regenerative medicine · 2026Review
- Toward 4D printed functional soft tissues.Acta biomaterialia · 2026Review
- Rapid Deep Vat Printing Using Photoclickable Collagen-Based Bioresins.Advanced healthcare materials · 2025Article
- Converging Architectures: Precision Biomanufacturing and Soft Robotics Rewiring Tissue Engineering.Micromachines · 2025Article
- Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?Bioactive materials · 2025Review
- Multicellular muscle-tendon bioprinting of mechanically optimized musculoskeletal bioactuators with enhanced force transmission.Science advances · 2025Article
- 3D bioprinted multi-layered cell constructs with gradient core-shell interface for tendon-to-bone tissue regeneration.Bioactive materials · 2025Article
- Advances focusing on the application of decellularization methods in tendon-bone healing.Journal of advanced research · 2025Review
- Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair.Biomaterials research · 2025Review
- Automated Microfluidics-Assisted Hydrogel-Based Wet-Spinning for the Biofabrication of Biomimetic Engineered Myotendinous Junction.Advanced healthcare materials · 2024Article
- Engineering interfacial tissues: The myotendinous junction.APL bioengineering · 2024Review
- An engineered in vitro model of the human myotendinous junction.Acta biomaterialia · 2024Article
- Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction.Science advances · 2024Article
- Tumor-on-a-chip models combined with mini-tissues or organoids for engineering tumor tissues.Theranostics · 2024Review
- Arthroscopy Technique: Repair of Musculotendinous Junction Rotator Cuff Tears in the Shoulder Using a Dynamic Convergence Suture Bridge Technique.Arthroscopy techniques · 2023Article
- Review
- 3D bioprinting using a new photo-crosslinking method for muscle tissue restoration.NPJ Regenerative medicine · 2023Article
- Hybrid cell constructs consisting of bioprinted cell-spheroids.Bioengineering & translational medicine · 2023Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the musculoskeletal system, the myotendinous junction (MTJ) is optimally designed from the aspect of force transmission generated from a muscle through a tendon onto the bone to induce movement. Although the MTJ is a key complex tissue in force transmission, the realistic fabrication, and formation of complex tissues can be limited. To obtain the MTJ construct, we prepared two bioinks, muscle- and tendon-derived decellularized extracellular matrix (dECM), which can induce myogenic and tenogenic differentiation of human adipose-derived stem cells (hASCs). By using a modified bioprinting process supplemented with a nozzle consisting of a single-core channel and double-sheath channels, we can achieve three different types of MTJ units, composed of muscle, tendon, and interface zones. Our results indicated that the bioprinted dECM-based constructs induced hASCs to myogenic and tenogenic differentiation. In addition, a significantly higher MTJ-associated gene expression was detected at the MTJ interface with a cell-mixing zone than in the other interface models. Based on the results, the bioprinted MTJ model can be a potential platform for understanding the interaction between muscle and tendon cells, and even the bioprinting method can be extensively applied to obtain complex tissues.
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