Evidence map›Paper›PMID 36176581›Full record

ReviewFrontiers in cellular and infection microbiology2022

The science behind TCM and Gut microbiota interaction-their combinatorial approach holds promising therapeutic applications.

Wenrui Xia, Bei Liu, Shiyun Tang, Muhammad Yasir, Imran Khan

Erratum issuedAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Frontiers in pharmacology · 2026
    Article
  9. Therapeutic Potential ofFood science & nutrition · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. A Prospective Observational Study on the Effects ofInfection and drug resistance · 2025
    Article
  14. Article
  15. Analysis of composition of gut microbial community in a rat model of functional dyspepsia treated with Simo Tang.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Repairing gut barrier by traditional Chinese medicine: roles of gut microbiota.Frontiers in cellular and infection microbiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wenrui XiaThe First Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Bei LiuChengdu University of Traditional Chinese Medicine, Chengdu, China.
Shiyun TangNational Drug Clinical Trial Agency, Teaching Hospital of Chengdu University of Traditional Chinese Medicine (TCM), Chengdu, China.
Muhammad YasirSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Imran KhanDepartment of Biotechnology, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The trend toward herbal medicine as an alternative treatment for disease medication is increasing worldwide. However, insufficient pharmacologic information is available about the orally taken medicines. Not only herbal medicine, but also Western drugs, when passing through the gastrointestinal tract, interact with trillions of microbes (known as the gut microbiome [GM]) and their enzymes. Gut microbiome enzymes induce massive structural and functional changes to the herbal products and impact the bioavailability and efficacy of the herbal therapeutics. Therefore, traditional Chinese medicine (TCM) researchers extend the horizon of TCM research to the GM to better understand TCM pharmacology and enhance its efficacy and bioavailability. The study investigating the interaction between herbal medicine and gut microbes utilizes the holistic approach, making landmark achievements in the field of disease prognosis and treatment. The effectiveness of TCM is a multipathway modulation, and so is the GM. This review provides an insight into the understanding of a holistic view of TCM and GM interaction. Furthermore, this review briefly describes the mechanism of how the TCM-GM interaction deals with various illnesses.

Indexed as

Drugs, Chinese HerbalGastrointestinal MicrobiomeMedicine, Chinese TraditionalDrugs, Chinese HerbalChinese medicinegut microbiotamedicineprebioticsTCMTCM-bacteria interactionTCM-microbiota interaction

Identifiers

PMID36176581
PMCPMC9513201

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.