Evidence map›Paper›PMID 36176465›Full record

Trial reportFrontiers in endocrinology2022

Development and validation of a nomogram model for cancer-specific survival of patients with poorly differentiated thyroid carcinoma: A SEER database analysis.

Shuai Jin, Huiying Liu, Jingyuan Yang, Jie Zhou, Dandan Peng, Xiangmei Liu, Haiwang Zhang, Zhu Zeng, Yuan-Nong Ye

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact.Virchows Archiv : an international journal of pathology · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuai JinBioinformatics and Biomedical Big Data Mining Laboratory, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Department of Medical Informatics, School of Big Health, Guizhou Medical University, Guiyang, China.
Huiying LiuBioinformatics and Biomedical Big Data Mining Laboratory, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Department of Medical Informatics, School of Big Health, Guizhou Medical University, Guiyang, China.
Jingyuan YangSchool of Public Health, Guizhou Medical University, Guiyang, China.
Jie ZhouDepartment of Chronic Disease Surveillance Guizhou Center for Disease Control and Prevention, Guiyang, China.
Dandan PengClinical Medical School, Guizhou Medical University, Guiyang, China.
Xiangmei LiuClinical Medical School, Guizhou Medical University, Guiyang, China.
Haiwang ZhangClinical Medical School, Guizhou Medical University, Guiyang, China.
Zhu ZengEngineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Biology and Engineering, Guizhou Medical University, Guiyang, China.
Yuan-Nong YeBioinformatics and Biomedical Big Data Mining Laboratory, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Department of Medical Informatics, School of Big Health, Guizhou Medical University, Guiyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to establish and validate an accurate prognostic model, based on demographic and clinical parameters, for predicting the cancer-specific survival (CSS) of patients with poorly differentiated thyroid carcinoma (PDTC). Materials and methods: Patients diagnosed with PDTC between 2004 to 2015 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Randomly split the data into training and validation sets. Kaplan-Meier analysis with the log-rank test was performed to compare the survival distribution among cases. Univariate and multivariate Cox proportional hazards regression analyses were used to identify independent prognostic factors, which were subsequently utilized to construct a nomogram for predicting the 5- and 10-year cancer-specific survival of patients with PDTC. The discriminative ability and calibration of the nomogram model were assessed using the concordance index and calibration plots, respectively. In addition, we performed a decision curve analysis to assess the clinical value of the nomogram. Simultaneously, we compared the predictive performance of the nomogram model against that of the American Joint Committee on Cancer (AJCC) T-, N-, M-stage. Results: A total of 970 eligible patients were randomly assigned to either a training cohort ( Conclusions: The nomogram developed by us can accurately predict the CSS of PDTC patients. It can help clinicians determine appropriate treatment strategies for poorly differentiated thyroid carcinoma patients.

Indexed as

AdenocarcinomaThyroid NeoplasmsHumansNeoplasm StagingNomogramsSEER Programcancer-specific survivalnomogrampoorly differentiated thyroid carcinomaprognostic modelSEER database

Identifiers

PMID36176465
PMCPMC9513392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.