Evidence map›Paper›PMID 36176456›Full record

ArticleFrontiers in pharmacology2022

Schisandrin alleviates the cognitive impairment in rats with Alzheimer's disease by altering the gut microbiota composition to modulate the levels of endogenous metabolites in the plasma, brain, and feces.

Chengqin Zhang, Ying Zhang, Tiantian Zhao, Tingting Mou, Wang Jing, Jian Chen, Wenqian Hao, Shuo Gu, Meirong Cui, Yue Sun and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. A comprehensive review on Schisandrin and its pharmacological features.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chengqin ZhangPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Ying ZhangPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Tiantian ZhaoPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Tingting MouPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Wang JingPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Jian ChenPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Wenqian HaoPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Shuo GuPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Meirong CuiPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Yue SunPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
Binbin WeiPharmacy Teaching Experimental Center, School of Pharmacy, China Medical University, Shenyang, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schisandrin is one of the main active compounds isolated from the fruit of

Indexed as

16S rRNA gene sequencingAlzheimer’s diseasegut microbiotametabolomicsschisandrin

Identifiers

PMID36176456
PMCPMC9514097
OpenAlexW4295234978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.