Evidence map›Paper›PMID 36176450›Full record

ArticleFrontiers in pharmacology2022

Traditional Chinese decoction Si Zhi Wan attenuates ovariectomy (OVX)-induced bone loss by inhibiting osteoclastogenesis and promoting apoptosis of mature osteoclasts.

Qingman He, Kanghua Fu, Huan Yao, Shujun Wei, Li Xiang, Sixian Liu, Tao Chen, Yongxiang Gao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Qingman HeAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Kanghua FuAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Huan YaoAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Shujun WeiSichuan Police College, Luzhou, China.
Li XiangAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Sixian LiuAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tao ChenAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yongxiang GaoAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu University of Traditional Chinese Medicine · CNShanghai Police College · CNUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Si Zhi Wan (SZW) is a traditional Chinese decoction used for osteoporosis treatment. Currently, the effect of SZW on ovariectomy (OVX)-induced bone loss and the underlying mechanisms remain unknown. Herein, we investigated the therapeutic effect of SZW on osteoporosis and explored the underlying mechanisms

Indexed as

apoptosisNF-κB signaling pathwayosteoclastogenesisSi Zhi Wantraditional Chinese decoction

Identifiers

PMID36176450
PMCPMC9513524
OpenAlexW4295532921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.